Cardiovascular and skeletal muscle health with lifelong exercise

Journal of Applied Physiology
Kevin J GriesScott Trappe

Abstract

The purpose of this study was to examine the effects of aerobic lifelong exercise (LLE) on maximum oxygen consumption (V̇o2max) and skeletal muscle metabolic fitness in trained women ( n = 7, 72 ± 2 yr) and men ( n = 21, 74 ± 1 yr) and compare them to old, healthy nonexercisers (OH; women: n = 10, 75 ± 1 yr; men: n = 10, 75 ± 1 yr) and young exercisers (YE; women: n = 10, 25 ± 1 yr; men: n = 10, 25 ± 1 yr). LLE men were further subdivided based on intensity of lifelong exercise and competitive status into performance (LLE-P, n = 14) and fitness (LLE-F, n = 7). On average, LLE exercised 5 day/wk for 7 h/wk over the past 52 ± 1 yr. Each subject performed a maximal cycle test to assess V̇o2max and had a vastus lateralis muscle biopsy to examine capillarization and metabolic enzymes [citrate synthase, β-hydroxyacyl-CoA dehydrogenase (β-HAD), and glycogen phosphorylase]. V̇o2max had a hierarchical pattern (YE > LLE > OH, P < 0.05) for women (44 ± 2 > 26 ± 2 > 18 ± 1 ml·kg-1·min-1) and men (53 ± 3 > 34 ± 1 > 22 ± 1 ml·kg-1·min-1) and was greater ( P < 0.05) in LLE-P (38 ± 1 ml·kg-1·min-1) than LLE-F (27 ± 2 ml·kg-1·min-1). LLE men regardless of intensity and women had similar capillarization and aerobic enzyme activity (citrate synth...Continue Reading

References

Oct 1, 1975·Acta Physiologica Scandinavica·P Andersen
Sep 1, 1977·The Journal of Physiology·P Andersen, J Henriksson
Jan 1, 1990·Journal of Applied Physiology·L J TarnopolskyJ R Sutton
May 1, 1990·Journal of Applied Physiology·A R CogganJ O Holloszy
Mar 1, 1983·The American Journal of Physiology·M M ChiO H Lowry
Sep 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G W HeathJ O Holloszy
Jun 1, 1995·Journal of Applied Physiology·D N ProctorP W Lemon
Mar 1, 1995·Journal of Applied Physiology·S W TrappeD R Pearson
Mar 1, 1994·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Y BhambhaniG Bell
Nov 1, 1993·Journal of Applied Physiology·A R CogganP M Robitaille
May 1, 1997·Journal of Applied Physiology·M L PollockJ H Wilmore
Jan 1, 1997·European Journal of Applied Physiology and Occupational Physiology·P F McLarenS H Boutcher
Feb 26, 1998·Journal of Applied Physiology·D N ProctorM J Joyner
Jan 25, 2000·Circulation·B M PluimE E van der Wall
Mar 31, 2000·Clinics in Sports Medicine·D A Lopiano
Jan 12, 2001·Journal of the American College of Cardiology·H TanakaD R Seals
Mar 13, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·E LevadouxP Ritz
Oct 5, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R A WiswellE T Schroeder
Mar 15, 2002·The New England Journal of Medicine·Jonathan MyersJ Edwin Atwood
Jan 1, 1962·Scandinavian Journal of Clinical and Laboratory Investigation·L ERIKSENS HAAVALDSEN
Sep 15, 2004·Circulation·Armin Arbab-ZadehBenjamin D Levine
Jul 12, 2005·Exercise and Sport Sciences Reviews·Mark A Febbraio, Bente K Pedersen
Aug 22, 2008·Diabetes·Ian R LanzaK Sreekumaran Nair
May 21, 2009·JAMA : the Journal of the American Medical Association·Satoru KodamaHirohito Sone
Dec 17, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Todd A TrappeChris J Hollon
Feb 15, 2012·The Journal of Physiology·Naoki FujimotoBenjamin D Levine
Mar 13, 2012·Cell Metabolism·Romain BarrèsJuleen R Zierath
Oct 16, 2012·Journal of Applied Physiology·Scott TrappePer Tesch
Oct 1, 2013·Journal of Strength and Conditioning Research·Dan M CushmanMonica Rho
Jan 25, 2014·Journal of Applied Physiology·Graeme Carrick-RansonBenjamin D Levine
Sep 23, 2014·Journal of the American College of Cardiology·Paul S BhellaBenjamin D Levine
Jan 8, 2015·The Journal of Physiology·Ross D PollockStephen D R Harridge
Mar 4, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Christina J CharlesworthMichelle C Odden
Aug 11, 2015·Medicine and Science in Sports and Exercise·Cemal OzemekLeonard A Kaminsky
Oct 11, 2015·Bone·Svenia Schnyder, Christoph Handschin
Jan 29, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Todd A TrappeScott W Trappe
Mar 14, 2017·Progress in Cardiovascular Diseases·Matthew P HarberRobert Ross
Aug 18, 2017·Medicine and Science in Sports and Exercise·Sarah EvermanJack T Daniels

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Citations

Feb 7, 2019·Physiology·Kaleen M LavinMarcas M Bamman
Mar 1, 2019·Circulation Research·Carl J LavieSteven N Blair
Jun 4, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James McKendryLeigh Breen
Jul 18, 2019·The New England Journal of Medicine·Austin T RobinsonWilliam B Farquhar
Dec 13, 2019·Journal of Applied Physiology·Toby L ChambersScott Trappe
Apr 19, 2019·Exercise and Sport Sciences Reviews·Nicholas T BroskeyLeanne M Redman
Nov 22, 2019·Journal of Applied Physiology·Kaleen M LavinTodd A Trappe
Nov 2, 2019·Journal of Applied Physiology·Kevin J GriesScott Trappe
Sep 24, 2020·The Journal of Physiology·L N OlsenY Hellsten
Jul 20, 2019·Oxidative Medicine and Cellular Longevity·Jesus R HuertasSara Cogliati
Jan 16, 2020·Scientific Reports·Aliza B RubensteinStuart C Sealfon
Aug 14, 2020·Journal of Applied Physiology·Stephan van der ZwaardArno Knobbe
Nov 19, 2020·Scandinavian Journal of Medicine & Science in Sports·Martin BahlsMarcus Dörr
Oct 16, 2020·Journal of Applied Physiology·Kaleen M LavinTodd A Trappe
Mar 7, 2021·Mayo Clinic Proceedings·Mark W PatakyK Sreekumaran Nair
Jul 18, 2019·The New England Journal of Medicine·Pedro L ValenzuelaAlejandro Lucia
Apr 13, 2021·Medicine and Science in Sports and Exercise·Lasse GliemannYlva Hellsten
May 26, 2021·Journal of Aging and Physical Activity·Oliver VogelLutz Vogt
Jun 4, 2021·Journal of Applied Physiology·Jorge Pérez-GómezYlva Hellsten
Jun 11, 2021·Physiological Reports·Sophia Z LiuDavid J Marcinek
May 27, 2021·The Journal of Physiology·Gregory J GrosickiScott Trappe
May 22, 2019·Journal of the American Medical Directors Association·Pedro L ValenzuelaAlejandro Lucia
Jul 10, 2021·Journal of American College Health : J of ACH·Peter C DourisMin-Kyung Jung
May 6, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·G VarescoV Rozand
Aug 17, 2021·Medicine and Science in Sports and Exercise·Heath M BurtonEdward F Coyle
Aug 27, 2021·Journal of Applied Physiology·Andrew M StrohScott W Trappe
Jul 3, 2021·European Journal of Applied Physiology·A ManciniP Buono
Aug 19, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Giorgio VarescoVianney Rozand
Oct 10, 2021·Sports Medicine - Open·Martin Kopp, Martin Burtscher
Nov 20, 2021·Annual Review of Medicine·Graeme Carrick-RansonBenjamin D Levine

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Methods Mentioned

BETA
biopsy
biopsies
X-ray

Software Mentioned

NIH ImageJ
Statistical Analysis Software ( SAS
enCORE
cellSens

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