Cardiovascular Changes After Gastric Bypass Surgery: Involvement of Increased Secretions of Glucagon-Like Peptide-1 and Brain Natriuretic Peptide

Obesity Surgery
Maria-Pia GandolfiniSéverine Ledoux

Abstract

Obesity induces cardiovascular alterations, including cardiac hypertrophy, impaired relaxation, and heart rate variability (HRV), which are associated with increased mortality. Gastric bypass surgery (GBP) reduces cardiovascular mortality, but the mechanisms involved are not clearly established. To date, the implication of postsurgical hormonal changes has not been tested. Our aim was to study the relationships between the evolution of cardiovascular functions after GBP and changes in metabolic and hormonal parameters, including glucagon-like peptide-1 (GLP-1) and brain natriuretic peptide (N-terminal pro-brain natriuretic peptide (NT-proBNP)). Echocardiographic parameters, 24-h rhythmic Holter recording, plasma concentrations of GLP-1 before and after a test meal, and fasting NT-proBNP were assessed in 34 patients (M/F 2/32, age 36 ± 11 years, BMI 46 ± 6 kg/m(2)), before and 1 year after GBP. After GBP, excess weight loss was 79 ± 20%. Blood pressure (BP), heart rate, and left ventricular mass decreased, while HRV and diastolic function (E/A ratio) improved. Plasma concentrations of NT-proBNP and postprandial (PP) GLP-1 increased. Changes in cardiovascular parameters were related to BMI and insulin sensitivity. Furthermore, th...Continue Reading

References

Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Dec 16, 2005·Obesity Surgery·M LavilleA Basdevant
Jun 24, 2010·The American Journal of Medicine·Mohamed F AlgahimHeinrich Taegtmeyer
Dec 21, 2010·Cardiovascular Therapeutics·Theodore Okerson, Robert J Chilton
Aug 19, 2011·The Journal of Clinical Endocrinology and Metabolism·Abigail May KhanThomas J Wang
Jan 10, 2012·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Raelene E MaserGail M Wynn
Feb 7, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Mohamed F AlgahimHeinrich Taegtmeyer
Feb 11, 2012·Endocrine Reviews·John R Ussher, Daniel J Drucker
Oct 19, 2012·Heart·Amanda R VestJames B Young
Dec 29, 2012·The Journal of Clinical Endocrinology and Metabolism·Nora E StraznickyElisabeth A Lambert
Mar 5, 2013·Obesity Surgery·Niclas AbrahamssonF Anders Karlsson
May 29, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Kirk T SpencerRobert J Siegel

❮ Previous
Next ❯

Citations

Jun 11, 2016·Basic Research in Cardiology·Yang YangWei Yi
Mar 29, 2019·Circulation Research·Manan PareekPhilip R Schauer
Nov 30, 2020·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Lihu GuPing Chen
May 8, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Cicero Jonas R BenjamimVitor E Valenti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.