PMID: 8586121Oct 1, 1995Paper

Cardiovascular changes during acute episodic repetitive hypoxic and hypercapnic breathing in rats

The European Respiratory Journal
M BakeheP Escourrou

Abstract

It has been shown that chronic repetitive ambient hypoxia, simulating pulmonary gas disturbances observed in apnoea, leads to systemic hypertension in rats. However, the relative roles of hypoxia (HO), hypercapnia (HC), gas stress and vigilance on the cardiovascular changes have not yet been demonstrated. The aim of this study was to investigate the acute haemodynamic changes observed during the repetitive inhalation of various gas mixtures in rats for HO alone and HO+HC, and to analyse the effects of vigilance and of the stress of gas administration. We studied 6 unanaesthetized Wistar rats chronically instrumented with an aortic catheter. Nitrogen, nitrogen+CO2 mixtures and compressed air were randomly administered in a Plexiglass chamber for 10 s and then flushed by compressed air for 20 s. Two cycles were repeated every min for 10 to 12 min. The inhaled gas fractions (FI,O2,FI,CO2) were monitored by O2 and CO2 analysers. Blood pressure (BP) was measured by a P23XL transducer. The blood gases were analysed by a 1306 IL meter. In control experiments, with compressed air alone, there were no significant acute changes in heart rate (HR) and BP. During HO there were no changes in HR or BP at FI,O2 values from 0.05-0.14, whilst a...Continue Reading

Citations

Oct 27, 2007·American Journal of Respiratory and Critical Care Medicine·Maurice DematteisEvelyne Gozal
Jun 17, 2008·Acta Cirúrgica Brasileira·Olivia Adayr Xavier Suarez, Katsumasa Hoshino
Mar 18, 2005·Journal of Applied Physiology·Paul C JohnsonMarcos Intaglietta

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