Cardiovascular Complications and Their Association With Mortality in Patients With Thrombotic Thrombocytopenic Purpura.

The American Journal of Medicine
Nivas BalasubramaniyamWilliam H Frishman

Abstract

Despite widespread availability of plasmapheresis, the mortality in thrombotic thrombocytopenic purpura remains high. Cardiovascular complications have been reported as an important cause of morbidity in these patients. The burden and prognostic implications of these complications have not been well studied. We analyzed the rates of cardiovascular complications in thrombotic thrombocytopenic purpura, temporal trends, and studied its impact on in-hospital mortality. We analyzed the National Inpatient Sample (NIS) from January 2005 to September 2015 to identify adult patients with thrombotic thrombocytopenic purpura. This group was further refined by excluding patients who did not receive therapeutic plasmapheresis, and other conditions that can mimic thrombotic thrombocytopenic purpura. We identified the age- and sex-stratified rates of cardiac arrhythmias, cardiac conduction system disorders, heart failure, acute coronary syndrome, myocarditis, pericarditis, takotsubo cardiomyopathy, cardiogenic shock, cardiac arrest, and stroke. We also compared in-hospital mortality with and without cardiovascular complications. Among 15,054 thrombotic thrombocytopenic purpura hospitalizations (mean age 46.4 years, 69% in the 18- to 54-age gr...Continue Reading

References

Aug 23, 2002·The New England Journal of Medicine·Joel L Moake
May 4, 2005·The American Journal of Medicine·Apoor S GamiVesna D Garovic
Jan 10, 2006·British Journal of Haematology·B F WyllieUNKNOWN Members of the Canadian Apheresis Group
Apr 1, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel PatschanStefan Herget-Rosenthal
May 5, 2006·The New England Journal of Medicine·James N George
Dec 25, 2009·Blood·Johanna A Kremer HovingaJames N George
Sep 3, 2013·The American Journal of Medicine·Nivas BalasubramaniyamWilliam H Frishman
Sep 10, 2014·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Larry NicholsJay S Raval
Oct 19, 2016·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Donald M ArnoldIshac Nazy

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Citations

Jul 17, 2021·Medicina clínica·María Eva Mingot CastellanoUNKNOWN Grupo Español de Aféresis (GEA)
Oct 14, 2021·Annals of Hematology·Julio Del Río-GarmaUNKNOWN “Registro Español de la Púrpura Trombocitopénica Trombótica (REPTT)”, and the “Grupo Español de Aféresis (GEA)”

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