Cardiovascular complications of sickle cell disease.

Trends in Cardiovascular Medicine
Vandana SachdevSwee Lay Thein

Abstract

Sickle cell disease (SCD) is the most common inherited blood disorder in the United States, and a global health problem. Pathological features of the abnormal hemoglobin (HbS) result in 2 hallmarks of the disease - recurrent episodes of acute microvascular occlusion and chronic hemolytic anemia - that inflict continuous and insidious damage to multiple organs. With improved childhood survival, SCD in adults has evolved into a chronic degenerative disease with underlying damage to multiple organs including the heart and lungs. Cardiopulmonary complications, including cardiomyopathy, diastolic dysfunction, pulmonary hypertension (PH), and sudden cardiac death are the most common causes of morbidity and mortality. Awareness of the sickle-related cardiovascular phenotypes is important for screening, early diagnosis, and intervention of cardiac complications in this disorder.

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Citations

Jan 29, 2021·British Journal of Haematology·Vandana SachdevSwee Lay Thein
Jul 6, 2021·Current Opinion in Pulmonary Medicine·Clare C Prohaska, Roberto F Machado
Oct 10, 2021·American Journal of Hematology·Solomon JohnsonMehdi Nouraie

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