Cardiovascular Concerns in BRCA1 and BRCA2 Mutation Carriers.

Current Treatment Options in Cardiovascular Medicine
Kelly C GastKathryn J Ruddy

Abstract

BRCA1 and BRCA2 mutation carriers can be at increased cardiovascular risk. The goal of this review is to provide information about factors associated with increased cardiovascular risk, methods to prevent cardiovascular toxicities, and recommended screening guidelines. BRCA1/2 mutation carriers who are diagnosed with cancer are often exposed to chemotherapy, chest radiotherapy, and/or HER2 directed therapies, all of which can be cardiotoxic. In addition, BRCA1/2 carriers often undergo prophylactic salpingoopherectomies, which may also increase cardiovascular risks. Understanding the potential for increased cardiovascular risk in individuals with a BRCA1 or BRCA2 mutation, as well as gold standard practices for prevention, detection, and treatment of cardiac concerns in this population, is important.

References

Nov 1, 1979·Annals of Internal Medicine·D D Von HoffF M Muggia
Nov 1, 1988·The American Journal of Medicine·L Oleksowicz, H W Bruckner
Jan 14, 1999·The New England Journal of Medicine·L C HartmannR B Jenkins
Apr 13, 2000·The New England Journal of Medicine·G M FelkerE K Kasper
Oct 3, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L J PierceB L Weber
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
Jun 22, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D CardinaleC M Cipolla
Feb 6, 2003·Journal of the National Cancer Institute·Stephan A HahnDetlef K Bartsch
Feb 26, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy R RebbeckBarbara L Weber
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O HequetB Coiffier
Jun 5, 2004·The Breast : Official Journal of the European Society of Mastology·T M SuterC Barton
Dec 31, 2005·The New England Journal of Medicine·UNKNOWN Breast International Group (BIG) 1-98 Collaborative GroupAron Goldhirsch
Jan 19, 2006·Cancer Chemotherapy and Pharmacology·Søren Astrup Jensen, Jens Benn Sørensen
Mar 15, 2006·Critical Reviews in Oncology/hematology·Emiliano HonradoJosé Palacios
Aug 5, 2006·The Lancet Oncology·UNKNOWN Arimidex, Tamoxifen, Alone or in Combination Trialists' GroupJ M Nabholtz
Sep 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Elvira C van DalenLeontien C M Kremer
Sep 26, 2006·Oncogene·C G Mathew
Feb 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Fergus J CouchRalph H Hruban
Jul 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Candace R CorreaEleanor E Harris
Jan 29, 2008·Current Treatment Options in Cardiovascular Medicine·Geoffrey C Clare, Richard W Troughton
Sep 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deann P AtchleyBanu K Arun
Nov 14, 2008·The New England Journal of Medicine·William D Foulkes
Nov 27, 2008·Menopause : the Journal of the North American Menopause Society·Cathleen M RiveraWalter A Rocca
Nov 7, 2009·Patient Education and Counseling·Neeraj K AroraArnold L Potosky
Feb 2, 2010·Journal of the American College of Cardiology·Daniela CardinaleCarlo M Cipolla
Feb 18, 2010·International Journal of Radiation Oncology, Biology, Physics·Sarah C DarbyRoy E Shore
Sep 3, 2010·JAMA : the Journal of the American Medical Association·Susan M DomchekTimothy R Rebbeck
Nov 3, 2010·European Journal of Pharmacology·El-Sayed E El-AwadyAsmaa Radwan
Dec 28, 2010·European Heart Journal·Erik IngelssonDaniel Altman
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup
Jul 15, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Paul McGaleMarianne Ewertz
Dec 14, 2011·The Journal of Biological Chemistry·Krishna K SinghSubodh Verma
Dec 24, 2011·Nature Reviews. Cancer·Rohini RoySimon N Powell
Jan 6, 2012·European Journal of Heart Failure·Carlo G TocchettiNicola Maurea
Apr 28, 2012·CA: a Cancer Journal for Clinicians·Cheryl L RockTed Gansler
May 10, 2012·Journal of the National Cancer Institute·Rachel Ballard-BarbashCatherine M Alfano

❮ Previous
Next ❯

Citations

Dec 11, 2019·Current Treatment Options in Cardiovascular Medicine·Avinash V SharmaAna Barac

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Related Papers

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Angela R BradburyOlufunmilayo I Olopade
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Timothy R Rebbeck
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Antonis C AntoniouD Gareth Evans
© 2022 Meta ULC. All rights reserved