Cardiovascular correlates of platelet count and volume in the Framingham Heart Study

Annals of Epidemiology
Arielle SloanAndrew D Johnson

Abstract

Platelet count and volume are inexpensive, routinely assayed biomarkers associated with cardiovascular health, but specific relationships among platelet indices, cardiovascular risk factors, and disease warrant further investigation. The purpose of this study was to understand associations among platelet count, volume, and 20 cardiovascular health-related variables in the Framingham Heart Study (FHS). Cross-sectional analyses were performed on platelet count and volume associations with cardiovascular health indicators in three FHS cohorts (original n = 964, offspring n = 2699, and third generation n = 2419) using multivariate linear regression analysis. Time-to-event analysis was used for cardiovascular disease-related event incidences using Kaplan-Meier plots and Cox proportional hazards regression adjusted for age and sex. Results were concordant with the hypothesis that higher platelet counts are associated with less favorable cardiovascular risk profiles, although mean platelet volume associations were weaker. In our analysis, increased platelet count across FHS cohorts was consistently associated with smoking, triglycerides, low-density lipoprotein, and total cholesterol levels. Some associations with platelet count appea...Continue Reading

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Citations

Mar 2, 2016·Blood·Nan Wang, Alan R Tall
Jun 28, 2016·American Journal of Human Genetics·John D EicherAndrew D Johnson
Jun 27, 2017·Platelets·John D EicherAndrew D Johnson
Jun 12, 2018·Journal of Thrombosis and Haemostasis : JTH·B IzziC Cerletti
Jan 24, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Alaleh GheissariMehryar Mehrkash
Nov 7, 2019·Science Translational Medicine·Tessa J BarrettJeffrey S Berger
Aug 13, 2020·Circulation Research·Dong Heon LeeAndrew D Johnson
Aug 19, 2020·European Journal of Clinical Investigation·Guoxia DongLei Liu
Feb 12, 2019·Andrologia·Guangmin Yang, Mehmutjan Muzepper
Sep 6, 2020·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Rohil MalpaniJonathan N Grauer

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