PMID: 2303287Mar 1, 1990Paper

Cardiovascular depression and stabilization by central vasopressin in rats

Hypertension
Y ImaiK Yoshinaga

Abstract

The role of endogenous vasopressin in cardiovascular homeostasis was examined using vasopressin-deficient rats (Brattleboro) (n = 194) and their parent strain, Long-Evans rats (n = 181). Mean arterial pressure (blood pressure) and heart rate were measured every 4 seconds with or without infusion of drug solution for 21 hours, and mean values and their standard deviations (lability) were calculated. Blood pressure in Brattleboro rats (116 +/- 1.1 mm Hg, mean +/- SEM) was significantly higher than that in Long-Evans rats (96 +/- 0.7 mm Hg, p less than 0.001), whereas heart rates (381 +/- 3.3 and 375 +/- 2.9 beats/min, respectively) were similar. The lability of blood pressure and heart rate in Brattleboro rats (9.2 +/- 0.1 mm Hg and 42.3 +/- 0.7 beats/min) was also greater than that in Long-Evans rats (6.7 +/- 0.1 mm Hg, p less than 0.001 and 38.4 +/- 0.8 beats/min, p less than 0.01, respectively). In Brattleboro rats, intravenous vasopressin (0.1 ng/kg/min or 0.6 ng/kg/min) did not affect blood pressure, although it did reduce heart rate and decreased lability of blood pressure and heart rate. Intracerebroventricular (central) infusion of vasopressin (2 pg/kg/min) in Brattleboro rats induced initial hypertension and tachycardia ...Continue Reading

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Citations

Apr 15, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·H IwaseK Hotta
Mar 16, 2013·British Journal of Pharmacology·Sanja Milutinović-SmiljanićNina Japundžić-Žigon
Oct 18, 2012·Physiological Reviews·Taka-aki KoshimizuAkito Tanoue
Sep 16, 2021·Journal of Neurochemistry·Yu HasegawaMotohiro Morioka

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