PMID: 9435586Jan 22, 1998Paper

Cardiovascular depressor responses to stimulation of substantia nigra and ventral tegmental area

The American Journal of Physiology
G J Kirouac, J Ciriello

Abstract

Experiments were done in alpha-chloralose-anesthetized, paralyzed, and artificially ventilated rats to investigate the effect of L-glutamate (Glu) stimulation of the substantia nigra (SN) and ventral tegmental area (VTA) on arterial pressure (AP) and heart rate (HR). Glu stimulation of the SN pars compacta (SNC) elicited decreases in both mean AP (MAP; -18.9 +/- 1.3 mmHg; n = 52) and HR (-26.1 +/- 1.6 beats/min; n = 46) at 81% of the sites stimulated. On the other hand, stimulation of the SN pars lateralis or pars reticulata did not elicit cardiovascular responses. Stimulation of the adjacent VTA region elicited similar decreases in MAP (-18.0 +/- 2.6 mmHg; n = 20) and HR (-25.4 +/- 3.8 beats/min; n = 17) at approximately 74% of the sites stimulated. Intravenous administration of the dopamine D2-receptor antagonist raclopride significantly attenuated both the MAP (70%) and the HR (54%) responses elicited by stimulation of the transitional region where the SNC merges with the lateral VTA (SNC-VTA region). Intravenous administration of the muscarinic receptor blocker atropine methyl bromide had no effect on the magnitude of the MAP and HR responses to stimulation of the SNC-VTA region, whereas administration of the nicotinic rece...Continue Reading

References

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Citations

Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G J Kirouac, Q J Pittman
Sep 12, 2015·Synapse·Masoumeh HatamAli Nasimi
Feb 22, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John CirielloTanja Babic
Aug 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John Ciriello, Jason M Moreau
Jun 22, 2018·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·E V AleksandrovaA A Potapov
May 17, 2005·British Journal of Pharmacology·Kathleen Deschamps, Réjean Couture

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