Cardiovascular disease and androgens: a review

International Journal of Cardiology
Manu KaushikClaire Hunter

Abstract

Globally, cardiovascular disease is the single largest cause of mortality. The differences in pattern of cardiovascular disease between the two genders have not been explained properly. The spotlight has largely been focused on estrogens but no conclusive evidence has proven its role in reducing the incidence of cardiovascular disease. Consequently, androgens have attracted significant interest in explaining the gender difference in cardiovascular disease. More studies in last two decades have increased our knowledge about the effects of androgens on cardiovascular disease progression. Evidence for age related fall in testosterone levels in males and increasing cardiovascular events with age had lead to the postulation of idea of 'andropause or male menopause'. Unfortunately, for the last few decades the androgens have been highlighted as agents of abuse among athletes all over the world. There have been multiple reports of their association with sudden cardiac death and adverse cardiovascular outcomes when abused. Contrastingly, there has been an increasing prescription use of testosterone supplementation in various conditions related to androgen deficiency state and for many other off-label indications. Human observational st...Continue Reading

References

Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·A GrayC Longcope
Nov 16, 1970·JAMA : the Journal of the American Medical Association
May 1, 1984·The American Journal of Cardiology·W S DaiA Caggiula
Nov 1, 1981·The American Journal of Cardiology·J GutaiA Caggiula
Aug 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·R FujimotoS Eto
Apr 1, 1994·Medicine and Science in Sports and Exercise·M J Huie
Aug 11, 1998·Circulation·J D MarshR J Schiebinger
Mar 11, 1999·The American Journal of Cardiology·C M WebbP Collins
Apr 16, 1999·Circulation Research·P AlexandersenC Christiansen
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Henry A FeldmanJohn B McKinlay
Feb 19, 2002·Atherosclerosis·Yew Koon LimSai Kiang Lim
Feb 28, 2002·Cardiovascular Research·Raghvendra K DubeyEdwin K Jackson
Feb 28, 2002·Endocrinology·Shanhong LingKrishnankutty Sudhir
May 31, 2002·Journal of Endocrinological Investigation·K M EnglishK S Channer
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·A Elisabeth HakHuibert A P Pols
Sep 5, 2002·International Journal of Health Services : Planning, Administration, Evaluation·Eeva Ollila, Meri Koivusalo
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Judy R FreshourKaren L Vikstrom
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Michael ZitzmannEberhard Nieschlag
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Bronwyn A L CrawfordDavid J Handelsman
Jan 30, 2004·The New England Journal of Medicine·Ernani Luis Rhoden, Abraham Morgentaler
Apr 21, 2004·Circulation·Majon MullerYvonne T van der Schouw
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Chris J MalkinT Hugh Jones

❮ Previous
Next ❯

Citations

Feb 19, 2013·Pflügers Archiv : European journal of physiology·Randi J Parks, Susan E Howlett
Nov 22, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gijs Van PottelberghJan Degryse
Apr 11, 2013·Cardiovascular Diabetology·Filipa Mascarenhas-MeloFlávio Reis
Jan 2, 2013·Frontiers in Bioscience (Scholar Edition)·Pandu R GangulaDiane Moseberry
Mar 1, 2011·Journal of Geriatric Cardiology : JGC·Ernst R SchwarzRobert D Willix
Jan 2, 2014·Journal of Cardiovascular Translational Research·Reid G HendryDavid J Marchant
Sep 22, 2012·Clinical and Experimental Hypertension : CHE·Nicolaas T MalanLeoné Malan
Sep 5, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cristina M ArceUNKNOWN Women’s Health Initiative Investigators
Mar 24, 2011·The Journal of Sexual Medicine·Kew-Kim ChewAlexandra Bremner
Jun 17, 2011·The Journal of Sexual Medicine·Culley C Carson, Giuseppe Rosano
Oct 11, 2011·Journal of Neuroendocrinology·N Yamaguchi, K Yuri
May 16, 2012·British Journal of Pharmacology·Kristen J BubbAmrita Ahluwalia
Feb 27, 2015·Journal of Clinical Laboratory Analysis·Konstantinos AgiannitopoulosKlea Lamnissou
Jul 22, 2014·Andrologia·M NaifarK Jamoussi
May 27, 2015·Cardiovascular Drugs and Therapy·Pankaj MathurJawahar L Mehta
Mar 17, 2015·Current Atherosclerosis Reports·David Bishop-Bailey
Oct 25, 2012·International Journal of Cardiology·Daniela PasqualiAntonio Cittadini
Feb 18, 2014·Atherosclerosis·Charalambos VlachopoulosChristodoulos Stefanadis
Oct 17, 2016·World Neurosurgery·Ady ThienNicolas Kon Kam King
May 20, 2015·Molecular and Cellular Biology·Poulami BasuMarica Bakovic
Jun 8, 2012·The Journal of Clinical Endocrinology and Metabolism·Frederick C W Wu
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·S R PyeUNKNOWN EMAS Study Group
Mar 7, 2012·Expert Review of Clinical Immunology·DeLisa FairweatherLeslie T Cooper
Mar 18, 2017·Nature Reviews. Endocrinology·Eugenia MorselliDeborah J Clegg
Dec 11, 2019·Journal of Cardiovascular Translational Research·Margarida LorigoElisa Cairrao
Jun 18, 2011·Current Opinion in Obstetrics & Gynecology·Amanda N Kallen, Lubna Pal
Aug 17, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

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