PMID: 16515470Mar 7, 2006Paper

Cardiovascular disease in diabetes

Mini Reviews in Medicinal Chemistry
Sho-ichi YamagishiTsutomu Imaizumi

Abstract

Diabetes is associated with a marked increase in the risk of atherosclerotic vascular disorders, including coronary, cerebrovascular, and peripheral artery disease. Cardiovascular disease (CVD) could account for disabilities and high mortality rates in patients with diabetes. In this paper, we review the molecular mechanisms for accelerated atherosclerosis in diabetes, especially focusing on postprandial hyperglycemia, advanced glycation end products (AGEs) and the renin-angiotensin system. We also discuss here the potential therapeutic strategy that specifically targets CVD in patients with diabetes.

Citations

May 2, 2012·The Journal of Clinical Investigation·Kai Soo TanYunn-Hwen Gan
Apr 9, 2008·Journal of Leukocyte Biology·Kazuhiro OmoriThomas E Van Dyke
Nov 15, 2013·Antioxidants & Redox Signaling·Linda M HiebertAnil Kumar Mandal
Jan 30, 2009·Basic & Clinical Pharmacology & Toxicology·Rannveig Linda ThorisdottirJens Sandahl Christiansen
Nov 26, 2011·Canadian Journal of Physiology and Pharmacology·Glaucy Rodrigues de AraujoDaniela Caldeira Costa
Mar 24, 2010·Molecular and Cellular Biochemistry·José D MéndezVerna Méndez-Valenzuela

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