Cardiovascular disease markers in women with polycystic ovary syndrome with emphasis on asymmetric dimethylarginine and homocysteine.

Annals of Saudi Medicine
Ahmed M MohamadinAbdulrahman A Al-Saggaf

Abstract

Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. Little is known about cardiovascular risk factors in patients with PCOS. We investigated plasma markers of cardiovascular disease in Saudi women with PCOS, with an emphasis on asymmetric dimethylarginine (ADMA) and total homocysteine (tHcy). Fifty Saudi women with PCOS diagnosed by the Rotterdam criteria (mean age [SD] 30.2 [3.0] years) and 40 controls without PCOS (mean age 29.3 [2.5] years) had measyrements taken of clinical, metabolic, and hormonal parameters, including plasma ADMA, tHcy, lipoprotein (a) ([Lp(a)], and serum high sensitivity C-reactive protein (hs-CRP), nitric oxid, and fibrinogen. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR). Women with PCOS had significantly higher fasting insulin, HOMA-IR, and luteinizing hormone (LH) levels than healthy controls (P P P CONCLUSION: Our study revealed that Saudi women with PCOS had a significantly different levels of plasma markers of cardiovascular disease compared with normal controls. Therefore, clinicians who manage women with PCOS should follow up on these markers to reduce the risk of cardiovascular disease.

References

Mar 14, 2001·Circulation·G ParadisiA D Baron
Oct 9, 2002·Journal of Internal Medicine·G J Blake, P M Ridker
Sep 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Christian FleckGünter Stein
Dec 11, 2003·Atherosclerosis. Supplements·Steven R LentzSanjana Dayal
Sep 24, 2004·Atherosclerosis·Silvana C RomerioWalter E Haefeli
Aug 9, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Neetu TyagiSuresh C Tyagi
Sep 16, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·F J BroekmansB C J M Fauser
Nov 25, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ahmed BadawyOmar Abd El Aziz
Nov 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Dennis HeutlingHendrik Lehnert
Dec 7, 2007·The Journal of Clinical Endocrinology and Metabolism·Olivier ValkenburgJoop S E Laven
Mar 7, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Asa LindholmInger Sundström-Poromaa
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Djuro MacutSvetozar Damjanović
Jun 27, 2008·Human Reproduction·Soo Jin ChaeShin Yong Moon
Jul 29, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Aldo GalluzzoCarla Giordano
Sep 19, 2008·Journal of Cardiovascular Medicine·Francesco GiallauriaCarlo Vigorito
Nov 1, 2008·Diabetes Research and Clinical Practice·Katarzyna KrzyzanowskaGuntram Schernthaner
Dec 17, 2008·Women's Health·Charikleia D Christakou, Evanthia Diamanti-Kandarakis
Jan 24, 2009·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·S Malek-khosraviG Atefi

❮ Previous
Next ❯

Citations

Jun 2, 2011·Human Reproduction Update·Konstantinos A ToulisBasil C Tarlatzis
Jul 12, 2013·International Journal of Endocrinology and Metabolism·Pietro ScicchitanoMarco Matteo Ciccone
Jul 29, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elena E Grodnitskaya, Mark A Kurtser
Jul 16, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zehra KurdogluMertihan Kurdoglu
Aug 2, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B ÜnA Beyazıt
Oct 20, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ilijana MažibradaDjuro Macut
Nov 2, 2019·Biological Trace Element Research·Batool Hossein RashidiMohammad Javad Hosseinzadeh-Attar
May 1, 2021·Life Sciences·Basma Abdel Fattah HelalAbeer Abed Abo Zeid
Jul 8, 2011·Current Opinion in Obstetrics & Gynecology

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent Assay
ELISA

Software Mentioned

SPSS

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Lawrence H LinEdmund C Baracat
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Ilgin TürkçüoğluAyşe Kafkasli
© 2021 Meta ULC. All rights reserved