Abstract
Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. Little is known about cardiovascular risk factors in patients with PCOS. We investigated plasma markers of cardiovascular disease in Saudi women with PCOS, with an emphasis on asymmetric dimethylarginine (ADMA) and total homocysteine (tHcy). Fifty Saudi women with PCOS diagnosed by the Rotterdam criteria (mean age [SD] 30.2 [3.0] years) and 40 controls without PCOS (mean age 29.3 [2.5] years) had measyrements taken of clinical, metabolic, and hormonal parameters, including plasma ADMA, tHcy, lipoprotein (a) ([Lp(a)], and serum high sensitivity C-reactive protein (hs-CRP), nitric oxid, and fibrinogen. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR). Women with PCOS had significantly higher fasting insulin, HOMA-IR, and luteinizing hormone (LH) levels than healthy controls (P P P CONCLUSION: Our study revealed that Saudi women with PCOS had a significantly different levels of plasma markers of cardiovascular disease compared with normal controls. Therefore, clinicians who manage women with PCOS should follow up on these markers to reduce the risk of cardiovascular disease.
References
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Mar 15, 1997·Journal of the American College of Cardiology·S J HutchisonK Chatterjee
Mar 14, 2001·Circulation·G ParadisiA D Baron
Oct 9, 2002·Journal of Internal Medicine·G J Blake, P M Ridker
Sep 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Christian FleckGünter Stein
Dec 11, 2003·Atherosclerosis. Supplements·Steven R LentzSanjana Dayal
Sep 24, 2004·Atherosclerosis·Silvana C RomerioWalter E Haefeli
Aug 9, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Neetu TyagiSuresh C Tyagi
Feb 1, 2006·Vascular Medicine·Karsten SydowJohn P Cooke
Sep 16, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·F J BroekmansB C J M Fauser
Nov 25, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ahmed BadawyOmar Abd El Aziz
Jan 31, 2007·Hypertension·Narbeh MelikianMark T Kearney
Nov 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Dennis HeutlingHendrik Lehnert
Dec 7, 2007·The Journal of Clinical Endocrinology and Metabolism·Olivier ValkenburgJoop S E Laven
Feb 27, 2008·Renal Failure·Ishak Ozel TekinSinan Kadayifci
Mar 7, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Asa LindholmInger Sundström-Poromaa
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Djuro MacutSvetozar Damjanović
Jun 27, 2008·Human Reproduction·Soo Jin ChaeShin Yong Moon
Jul 29, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Aldo GalluzzoCarla Giordano
Sep 19, 2008·Journal of Cardiovascular Medicine·Francesco GiallauriaCarlo Vigorito
Oct 15, 2008·Clinical Science·Lisa J MoranHelena J Teede
Nov 1, 2008·Diabetes Research and Clinical Practice·Katarzyna KrzyzanowskaGuntram Schernthaner
Nov 26, 2008·Atherosclerosis·Sharmalar RajendranJohn D Horowitz
Dec 17, 2008·Women's Health·Charikleia D Christakou, Evanthia Diamanti-Kandarakis
Jan 24, 2009·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·S Malek-khosraviG Atefi
Mar 18, 2009·Circulation·Rainer H BögerRamachandran S Vasan
May 19, 2009·BioFactors·Ji Zhou, Richard C Austin
Citations
May 4, 2012·Human Reproduction·R L ThomsonJ D Buckley
Jun 2, 2011·Human Reproduction Update·Konstantinos A ToulisBasil C Tarlatzis
Jan 11, 2013·Human Reproduction Update·Mora MurriHector F Escobar-Morreale
Jul 12, 2013·International Journal of Endocrinology and Metabolism·Pietro ScicchitanoMarco Matteo Ciccone
Jul 29, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elena E Grodnitskaya, Mark A Kurtser
Jul 16, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Zehra KurdogluMertihan Kurdoglu
Jun 10, 2016·PloS One·Yuming MengShengming Dai
Aug 2, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B ÜnA Beyazıt
Oct 20, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ilijana MažibradaDjuro Macut
Nov 2, 2019·Biological Trace Element Research·Batool Hossein RashidiMohammad Javad Hosseinzadeh-Attar
Aug 23, 2018·Lipids in Health and Disease·Maha H DaghestaniArjumand Warsy
Nov 27, 2020·Curēus·Varshitha KondapaneniIvan Cancarevic
May 1, 2021·Life Sciences·Basma Abdel Fattah HelalAbeer Abed Abo Zeid
Jul 8, 2011·Current Opinion in Obstetrics & Gynecology