Cardiovascular disease prediction: do pulmonary disease-related chest CT features have added value?

European Radiology
Pushpa M JairamPROVIDI study-group

Abstract

Certain pulmonary diseases are associated with cardiovascular disease (CVD). Therefore we investigated the incremental predictive value of pulmonary, mediastinal and pleural features over cardiovascular imaging findings. A total of 10,410 patients underwent diagnostic chest CT for non-cardiovascular indications. Using a case-cohort approach, we visually graded CTs from the cases and from an approximately 10 % random sample of the baseline cohort (n = 1,203) for cardiovascular, pulmonary, mediastinal and pleural findings. The incremental value of pulmonary disease-related CT findings above cardiovascular imaging findings in cardiovascular event risk prediction was quantified by comparing discrimination and reclassification. During a mean follow-up of 3.7 years (max. 7.0 years), 1,148 CVD events (cases) were identified. Addition of pulmonary, mediastinal and pleural features to a cardiovascular imaging findings-based prediction model led to marginal improvement of discrimination (increase in c-index from 0.72 (95 % CI 0.71-0.74) to 0.74 (95 % CI 0.72-0.75)) and reclassification measures (net reclassification index 6.5 % (p < 0.01)). Pulmonary, mediastinal and pleural features have limited predictive value in the identification of...Continue Reading

References

May 15, 2002·Chest·Masao NakataKenji Eguchi
Jun 21, 2002·The New England Journal of Medicine·Richard W Light
Dec 20, 2002·Nature·Peter Libby
Aug 21, 2003·JAMA : the Journal of the American Medical Association·Umesh N KhotEric J Topol
Mar 10, 2007·Journal of Clinical Epidemiology·N Charlotte Onland-MoretPetra H M Peeters
Jan 16, 2008·Radiology·David M HansellJacques Remy
Feb 25, 2009·BMJ : British Medical Journal·Karel G M MoonsDouglas G Altman
Feb 18, 2010·Journal of Cardiovascular Computed Tomography·Khurram NasirMatthew J Budoff
Sep 30, 2010·Radiology·Martijn J A GondrieUNKNOWN PROVIDI Study Group
Oct 5, 2010·European Journal of Epidemiology·M J A GondrieY van der Graaf
Nov 9, 2010·European Radiology·Martijn J A GondrieUNKNOWN PROVIDI Study Group
Feb 22, 2011·Radiologic Clinics of North America·Jeffrey B Alpert, David P Naidich
May 24, 2011·European Radiology·Peter C JacobsYolanda van der Graaf
Oct 25, 2011·PloS One·Pim A de JongUNKNOWN PROVIDI study group
Nov 16, 2011·Journal of Computer Assisted Tomography·Martijn J A GondrieUNKNOWN PROVIDI Study Group
Mar 21, 2012·Annals of Internal Medicine·Maryam KavousiJacqueline C M Witteman
Apr 28, 2012·American Journal of Respiratory and Critical Care Medicine·Stephan Van EedenDon D Sin
Aug 21, 2012·The Canadian Journal of Cardiology·S F Paul ManDon D Sin
Oct 11, 2012·JAMA : the Journal of the American Medical Association·Onno M MetsMathias Prokop
Jan 3, 2013·American Journal of Respiratory and Critical Care Medicine·Don D Sin, William MacNee
Jan 19, 2013·American Journal of Respiratory and Critical Care Medicine·Ane JohannessenPer Bakke

❮ Previous
Next ❯

Software Mentioned

project
R
PROVIDI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.