Cardiovascular disease prevalence and insulin resistance in the Kyushu-Okinawa Population Study and the Framingham Offspring Study

Journal of Clinical Lipidology
Hiroaki IkezakiNorihiro Furusyo

Abstract

Age-adjusted cardiovascular disease (CVD) prevalence rates are significantly lower in Japan than in the United States. Our aim was to compare CVD risk in participants in Fukuoka and Framingham. We measured glucose, insulin, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), small dense LDL-C, and triglycerides in men and women from Fukuoka (n = 1108), and age (median, 53 years) and gender-matched subjects from Framingham (n = 1101). Blood pressure, body mass index, use of medications, and history of CVD were also assessed. CVD prevalence rates were more than 6-fold higher in Framingham men and women than their Fukuoka counterparts (P < .001). Median body mass index, LDL-C, insulin levels, and insulin resistance assessment in Fukuoka men and women were significantly (P < .01) lower than in Framingham; however, diabetes prevalence in Fukuoka men was significantly (P < .01) higher than in Framingham men, whereas female rates were similar, as were levels of systolic blood pressure. High-density lipoprotein cholesterol and surprisingly small dense LDL-C levels were significantly (P < .001) higher in Fukuoka than in Framingham. Standard risk factors do not account for the large differences in CVD preva...Continue Reading

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Citations

Feb 7, 2019·Journal of Atherosclerosis and Thrombosis·Hung HsuMasumi Ai
Apr 14, 2020·Journal of Atherosclerosis and Thrombosis·Hiroaki IkezakiErnst J Schaefer
Jun 20, 2019·Frontiers in Endocrinology·Veronica Maria TagiFrancesco Chiarelli
Oct 30, 2020·Journal of Atherosclerosis and Thrombosis·Marie NakamuraMasumi Ai

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