Cardiovascular effect of almotriptan in treated hypertensive patients

Clinical Pharmacology and Therapeutics
Joseph C FleishakerBarbara J Carel

Abstract

Our objective was to investigate the cardiovascular effects of almotriptan, a 5-hydroxytryptamine 1B/1D agonist, in treated patients with hypertension. Twenty patients with hypertension controlled by medication received the following treatments in a randomized, double-blind, crossover design: one placebo tablet, one 12.5-mg almotriptan tablet, and one 25-mg almotriptan tablet. Serial blood samples for analysis of almotriptan were obtained through 24 hours after administration. Serial measurements of supine blood pressure, 12-lead electrocardiograms, and Holter electrocardiographic recordings were also obtained. Plasma almotriptan concentrations were measured with use of a liquid chromatography-tandem mass spectrometry assay. Differences between treatments in pharmacokinetic parameters were assessed with an ANOVA model appropriate for a crossover design. Blood pressure measures and QTc intervals were analyzed for treatment effects with use of a similar model. Analyses were performed on weighted mean and maximal changes from baseline for intervals from 0 to 4 and 0 to 12 hours after administration. Significant linear effects of dose were observed for the maximal change in diastolic blood pressure and for the maximal and mean chan...Continue Reading

Citations

Jul 2, 2003·Expert Opinion on Pharmacotherapy·David W Dodick
Dec 7, 2007·Expert Review of Neurotherapeutics·Miguel J A Láinez
Dec 5, 2002·Pharmacoepidemiology and Drug Safety
Oct 21, 2005·International Journal of Clinical Practice·G SandriniG Nappi

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