Cardiovascular effects in vitro of aqueous extract of wild strawberry (Fragaria vesca, L.) leaves

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
I MudnicM Boban

Abstract

In contrast to the strawberry fruits, strawberry leaves as a source of bioactive compounds with potentially beneficial biological effects have been largely overlooked. In this study we examined direct, dose-dependent effects of wild strawberry (Fragaria vesca, L.) leaves aqueous extract, in two experimental models and animal species, the isolated guinea pig hearts and rat aortic rings. Vasodilatory potential of the wild strawberry leaves extract was compared with vasodilatory activity of aqueous extract of hawthorn (Crataegus oxycantha, L) leaves with flowers, which can be regarded as a reference plant extract with a marked vasodilatory activity. The extracts were analysed by their "phenolic fingerprints", total phenolic content and antioxidative capacity. Their vasodilatory activity was determined and compared in the isolated aortic rings from 24 rats that were exposed to the extracts doses of 0.06, 0.6, 6, and 60 mg/100ml. Both extracts induced similar, dose-dependent vasodilation. Maximal relaxation was 72.2+/-4.4% and 81.3+/-4.5%, induced by the strawberry and hawthorn extract, respectively. To determine vasodilatory mechanisms of the wild strawberry leaves extract, endothelium-denuded and intact rings exposed to nitric oxi...Continue Reading

References

Jul 1, 1995·Journal of Cardiovascular Pharmacology·D F FitzpatrickR G Coffey
Apr 14, 2004·Critical Reviews in Food Science and Nutrition·Sandra M Hannum
Oct 7, 2004·European Journal of Pharmacology·Jean-Claude StocletValérie B Schini-Kerth
Feb 23, 2005·Nutrition·Jessica ScalzoMaurizio Battino
Mar 3, 2005·Nitric Oxide : Biology and Chemistry·Thomas WallerathUlrich Förstermann
Sep 22, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Aki NaemuraJunichiro Yamamoto
Dec 6, 2006·Journal of Ethnopharmacology·Snezana JarićPavle Pavlović
Nov 27, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kenji NishiokaYukihito Higashi

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Citations

May 14, 2014·Journal of Agricultural and Food Chemistry·Anna KårlundReijo O Karjalainen
Mar 23, 2011·Food Biophysics·Dorota Bonarska-KujawaHalina Kleszczyńska
Aug 17, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·C Del Bo'D Klimis-Zacas
Dec 14, 2011·Cellular & Molecular Biology Letters·Sylwia CyboranHalina Kleszczyńska
Mar 8, 2012·Cellular & Molecular Biology Letters·Dorota Bonarska-KujawaHalina Kleszczyńska
Jul 30, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Gorazd DrevenšekSamo Kreft
Nov 5, 2016·Journal of the Science of Food and Agriculture·Anna KårlundReijo O Karjalainen
Feb 23, 2020·Antioxidants·Joana CoutoMaria Eugénia Pina
Aug 9, 2018·Frontiers in Pharmacology·Khafsa MalikSyed N Shah
Jun 3, 2021·International Journal of Molecular Sciences·Jasmin FlemmingMatthias Hannig
Aug 18, 2020·Archives of Oral Biology·Jasmin KirschMatthias Hannig

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