Cardiovascular effects of a low-dose combination of ramipril and felodipine in spontaneously hypertensive rats

British Journal of Pharmacology
E M MervaalaH Karppanen

Abstract

1. Cardiovascular effects of submaximal antihypertensive doses of the angiotensin converting enzyme inhibitor, ramipril (0.25 mg kg-1 day-1 in the food), and the calcium channel blocker, felodipine (0.4 mg kg-1 day-1 subcutaneously by osmotic minipump), both alone and in combination, were examined in spontaneously hypertensive rats (SHR) in a four-week study. 2. Both ramipril and felodipine as monotherapy decreased systolic blood pressure. The antihypertensive effect of the drug combination was more than that of ramipril treatment alone, but not significantly better than that of felodipine monotherapy. Ramipril or felodipine treatments did not significantly affect the heart rate, either alone or in combination. 3. The beneficial effect of ramipril monotherapy on left ventricular hypertrophy was more prominent than that of felodipine. The cardioprotective effect of felodipine was improved when combined to ramipril. The systolic blood pressure at the end of the experimental period correlated only weakly with left ventricular hypertrophy. 4. Responses of mesenteric arterial rings in vitro were examined at the end of the four-week study. Ramipril and felodipine monotherapies as well as their combination markedly improved the endoth...Continue Reading

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Citations

Jun 20, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Paul Ernsberger, Richard J Koletsky
Apr 3, 2001·European Journal of Pharmacology·T K Jeffery, J C Wanstall
Jun 16, 1999·Clinical and Experimental Hypertension : CHE·S S Ozdem, C Oğütman
Jun 15, 2000·Blood Pressure·L LindJ Millgård
Jul 17, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Julia ZimmerBeate Rassler
Aug 2, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Pu Fang 方璞Hong Wang 王虹
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes

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