PMID: 40490Jan 1, 1979

Cardiovascular effects of a single injection of fentanyl in dogs under acute experimental conditions

Annales de l'anesthésiologie française
G PédrantG François


Experimental studies carried out in unselected dogs often face the problem of instabilit of various parameters both in terms of haemodynamics as well as acid-base balance. It is possible, with the injection of a single dose of Fentanyl of 0.35 given over a period of ten minutes to obtain, from the 30th minute after the injection, satisfactory cardiovascular stability (confirmed during 120 minutes in 9 dogs and 360 minutes in 2 of them). This haemodynamic state at T + 30 is obtained with a fall in mean blood pressure of -40 per cent, and an increase in peripheral resistance of +38 per cent and stroke volume of +11 per cent. This stability, obtained at the price of a stable normacapnia, correction of any possible metabolic acidosis and maintenance of body temperature, makes it possible to study the cardiovascular effects of certain types of treatment or of induced pathology.

Related Concepts

Evaluation of Acid-base Balance
Total Peripheral Resistance
Diastolic Blood Pressure
Insufflation Anesthesia
Pulmonary Vascular Resistance
Stroke Volume
Blood Pressure
Anion Gap
Cardiac Output

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