Cyclosporin A (CsA) is now routinely used for transplantation of all solid organs, bone marrow transplantation, and for an increasing number of immunological diseases. However, treatment with CsA is an important iatrogenic cause of post-transplant hypertension, hyperlipidemia, and diabetes, which may contribute to the high cardiovascular morbidity in transplant recipients. Recently, the calcineurin inhibitor CsA has been employed in vivo and in vitro to examine the role of calcineurin in the signal transduction leading to cardiac hypertrophy. A cell culture study demonstrated the inhibitory effect of CsA on cytokine production by cardiac myxoma cells, the most common primary tumor of the heart. This review discusses recent data on the cardiovascular effects of CsA.
Effects of steroid withdrawal on posttransplant diabetes mellitus in cyclosporine-treated renal transplant recipients
Systemic hypertension after cardiac transplantation: effect of cyclosporine on the renin-angiotensin-aldosterone system
Cyclosporin A augments angiotensin II-stimulated rise in intracellular free calcium in vascular smooth muscle cells
Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production
Intravenous cyclosporine activates afferent and efferent renal nerves and causes sodium retention in innervated kidneys in rats
Reversal of cyclosporine-inhibited low-density lipoprotein receptor activity in HepG2 cells by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
Diabetes mellitus after renal transplantation: as deleterious as non-transplant-associated diabetes?
Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin
Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure
Effects of nitric oxide blockade and cyclosporin A on cardiovascular and renal function in normal man
Upregulation of vasopressin V1A receptor mRNA and protein in vascular smooth muscle cells following cyclosporin A treatment
Simple renal cysts in hypertensive patients: relation between cyst growing and anti-hypertensive therapy
Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.