Cardiovascular effects of an immunosuppressive agent cyclosporin A

International Journal of Immunopathology and Pharmacology
H. Sakamoto, M. Kurabayashi

Abstract

Cyclosporin A (CsA) is now routinely used for transplantation of all solid organs, bone marrow transplantation, and for an increasing number of immunological diseases. However, treatment with CsA is an important iatrogenic cause of post-transplant hypertension, hyperlipidemia, and diabetes, which may contribute to the high cardiovascular morbidity in transplant recipients. Recently, the calcineurin inhibitor CsA has been employed in vivo and in vitro to examine the role of calcineurin in the signal transduction leading to cardiac hypertrophy. A cell culture study demonstrated the inhibitory effect of CsA on cytokine production by cardiac myxoma cells, the most common primary tumor of the heart. This review discusses recent data on the cardiovascular effects of CsA.

References

Feb 1, 1990·The American Journal of Physiology·C E JohansonM H Epstein
Jul 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N YoshimuraT Oka
Dec 26, 1989·The American Journal of Medicine·A MarmorA Schneeweiss
Apr 1, 1989·Diabetes·S L GillisonD L Curry
Dec 21, 1989·The New England Journal of Medicine·B D Kahan
Apr 1, 1987·Kidney International·R G Luke
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T HiranoF Sakiyama
Jan 1, 1986·Transplantation·H J HahnR Warzock
Mar 1, 1987·Medicine·M L MarkelW F Armstrong
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N G MossR J Falk
Jan 1, 1985·American Journal of Nephrology·E A FriedmanK M Butt
Jul 1, 1984·Diabetologia·A AnderssonA Schnell
Nov 1, 1984·Annals of Internal Medicine·D J CohenT B Strom
Apr 1, 1980·Transplantation·M G McGeownC M Hill
Dec 14, 1995·The New England Journal of Medicine·K Reynen
Sep 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O A RayyesC H Florén
Apr 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O al RayyesC H Florén
Jan 1, 1997·Annual Review of Immunology·A RaoP G Hogan
Sep 11, 1998·Science·M A SussmanJ D Molkentin
Oct 15, 1998·Nature Medicine·Z LuoK Walsh
Apr 28, 1999·Lancet·T ForceR Hajjar
Mar 7, 2000·Mediators of Inflammation·J E GarcíaJ L Arellano

Citations

Jun 12, 2003·International Journal of Immunopathology and Pharmacology·C SchiavoneM Di Gioacchino
Feb 13, 2003·International Journal of Immunopathology and Pharmacology·G RiccioniN D'Orazio

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