Cardiovascular effects of angiotensin II and glutamate in the PVN of Dahl salt-sensitive rats

Brain Research
Alexander Gabor, F H Leenen

Abstract

Several models of chronic sympathetic hyperactivity are associated with an increase in excitatory angiotensinergic and glutamatergic activity, and a decrease in GABAergic activity in the PVN. The present study evaluated whether activation of glutamate and AT1 receptors in the PVN contributes to the maintenance of resting BP in Dahl salt sensitive (S) rats on regular or high salt diet for 4-6 weeks. Candesartan and kynurenate were infused bilaterally into the PVN and BP and heart rate (HR) were recorded. Both candesartan and kynurenate in the PVN did not change MAP and HR in normotensive Dahl salt resistant (R) and S rats on regular salt diet or in R rats on high salt diet. In hypertensive Dahl S rats on high salt diet, candesartan decreased MAP (-14±2 mm Hg), and tended to increase HR (22±5 bpm). Kynurenate decreased both MAP (-22±3 mm Hg) and HR (-42±7 bpm) in these rats. At the peak BP decrease by candesartan, kynurenate in the PVN further decreased BP by ~50% (-14±2 mm Hg), whereas candesartan did not further decrease BP at the peak BP response to kynurenate (-4±2 mm Hg). These results indicate that activation of glutamate and AT1-receptors in the PVN contributes to the maintenance of BP in hypertensive Dahl S rats, but not ...Continue Reading

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Citations

Jul 10, 2012·Journal of Applied Physiology·Alexander Gabor, Frans H H Leenen
Apr 20, 2014·American Journal of Hypertension·Frans H H Leenen
Sep 21, 2017·Current Hypertension Reports·De-Pei Li, Hui-Lin Pan
Mar 30, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Lucas A C SouzaYumei Feng
Apr 12, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Robert A LarsonQing-Hui Chen
Aug 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Roger A DampneyHui-Lin Pan
Oct 1, 2019·Hypertension·Snigdha MukerjeeEric Lazartigues
Mar 29, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Megan E BardgettGlenn M Toney
Dec 7, 2018·Neuroscience Bulletin·Jing-Jing ZhouDe-Pei Li
Aug 1, 2012·Physiological Research·J ZichaJ Kuneš

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