Cardiovascular effects of aspidofractinine-type alkaloids from Kopsia

Journal of Natural Products
S L MokT S Kam

Abstract

Intravenous injection of the aspidofractinine alkaloid, kopsingine (1, 0.2-10.0 mg/kg) from Kopsia teoi, produced dose-related decreases in the mean arterial blood pressure and heart rate in anesthetized spontaneously hypertensive rats, which were similar to those seen in normotensive controls. Minor modifications in the molecular structure of kopsingine, as in kopsaporine (2, the 12-demethoxy derivative of kopsingine) and 14,15-dihydrokopsingine (4), did not significantly alter the hypotensive responses, whereas a more drastic change in the structure, as in the heptacyclic kopsidine A (3) and the 3-to-17 oxo-bridged compound 5, resulted in an increase in blood pressure. The antihypertensive effects of kopsingine (1) and its congeners (2 and 4) along with the pressor effects produced by the heptacyclic oxo-bridged compounds (5 and 3) could be ascribed to central as well as peripheral actions.

References

Feb 1, 1994·Journal of Ethnopharmacology·T SévenetH Schaller

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Citations

Jan 5, 1999·Bioorganic & Medicinal Chemistry Letters·T S KamK Komiyama
Jul 1, 2017·Fitoterapia·Ying WangFei Li
Jan 4, 2018·Journal of Asian Natural Products Research·Jin-Feng WangHai-Tao Wang
Jun 4, 2019·Journal of Asian Natural Products Research·Ting LiuMing-Wei Chen
Dec 7, 2019·Journal of Asian Natural Products Research·Xiao-Dong ChenFu-Sheng Chi

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