PMID: 8594309Jan 1, 1996Paper

Cardiovascular effects of centrally administered endothelin-1 and its relationship to changes in cerebral blood flow

Life Sciences
Anil GulatiB T Shahani

Abstract

Intracerebroventricular (i.c.v.) injection of endothelin-1 (ET-1; 100 ng. i.c.v.) produced an initial pressor (24%) (peak at 3 min following ET-1 administration) and a delayed depressor (-40%) (30 and 60 min following ET-1 administration) effects in urethane anesthetized rats. The pressor effect of ET-1 was due to an increase (21%) in cardiac output, while the depressor effect of ET-1 was associated with a marked decrease (-46%) in cardiac output. Stroke volume significantly decreased at 30 and 60 min after the administration of ET-1. No change in total peripheral vascular resistance and heart rate was observed following central administration of ET-1. The effects of ET-1 on Blood pressure, cardiac output and stroke volume were not observed in BQ123 (10 micrograms, i.c.v.) treated rats. Blood flow to the cerebral hemispheres, cerebellum, midbrain and brain stem was not affected at 3 min, but a significant decrease in blood flow to all the regions of the brain was observed at 30 and 60 min following central administration of ET-1. BQ123 pretreatment completely blocked the central ET-1 induced decrease in blood flow to the brain regions. It is concluded that the pressor effect of centrally administered ET-1 is not accompanied by ...Continue Reading

References

Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M W MacCumberS H Snyder
Jun 1, 1995·Brain : a Journal of Neurology·E PaulesuC D Frith

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Citations

Jul 4, 1998·European Journal of Pharmacology·N FernándezG Diéguez
Nov 7, 1998·British Journal of Pharmacology·A S FabricioG E Souza
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·R M Kedzierski, M Yanagisawa
May 23, 2006·Regulatory Peptides·Myrian R RodríguezLiliana G Bianciotti
Jun 15, 1999·Journal of Cardiovascular Pharmacology·K NakamuraM Nakagawa
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Avery W C Yip, Teresa L Krukoff
Feb 13, 2019·International Journal of Molecular Sciences·Michiel Van BulckJose A Morales-Garcia

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