Cardiovascular effects of copper deficiency on activity of superoxide dismutase in diabetic nephropathy

North American Journal of Medical Sciences
Mohammed A Al-BayatiHayder A Al-Aubaidy

Abstract

Copper (Cu) is essential both for its role in antioxidant enzymes, like Cu/zinc (Zn) superoxide dismutase (SOD) and ceruloplasmin, as well as its role in lysyl oxidase, essential for the strength and integrity of the heart and blood vessels. With such a central role in cardiovascular health, Cu has been generally overlooked in the debate over improving our cardiovascular health. Cu deficiency has produced many of the same abnormalities present in cardiovascular disease. It seems almost certain that Cu plays a large role in the development of this killer disease, not because of its excess in the diet, but rather its deficiency. This study was undertaken to investigate the cardiovascular effects of Cu deficiency on the activity of SOD in patients with type 2 diabetes mellitus (T2DM) with and without diabetic nephropathy. Fifty-five patients with T2DM were recruited in this study which were divided into two subgroups based on the presence of microalbuminuria, the first group (microal buminuric group, n = 31) had a microalbuminuria between 30 and 299 μg/mg. The second group (normoal buminuric group, n = 29) had an albumin level less than 30 μg/mg. The two diabetic groups were compared to the control group (n = 37). The results of o...Continue Reading

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Citations

Dec 14, 2017·Critical Reviews in Food Science and Nutrition·Noushin MohammadifardNizal Sarrafzadegan
May 6, 2019·Environmental Science and Pollution Research International·Muzammal RehmanDingxiang Peng
Oct 27, 2018·Open Heart·James J DiNicolantonioJames H O'Keefe
May 15, 2020·British Journal of Nursing : BJN·Evelyn Gyesi-AppiahAndrew Clifton
Nov 13, 2017·Pharmacological Reports : PR·Michal MajewskiJerzy Juskiewicz

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Methods Mentioned

BETA
glycosylation

Software Mentioned

VariantTM HbA1c

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