PMID: 9662783Jul 15, 1998Paper

Cardiovascular effects of enoximone and epinephrine on heparin reversal with protamine in conscious dogs

Veterinary Surgery : VS
Z SaritasS F Katircioglu

Abstract

To compare enoximone with epinephrine as treatments for the cardiotoxic effects of protamine sulfate. Prospective randomized study. 12 healthy cross-bred dogs weighing 23 +/- 4 kg. The dogs were anesthetized with xylazine and ketamine to allow instrumentation. Femoral arterial and venous catheters were inserted for pressure monitoring and to allow drug infusion. A thermodilution catheter mounted with a fast response thermistor was inserted into the pulmonary artery via the jugular vein to measure cardiac output and right ventricular volumes. Heparin 300 units/kg followed by protamine 4.5 mg/kg were administered 45 minutes after the xylazine/ketamine. Four animals were not treated (controls), four received enoximone, and four were given epinephrine. Cardiopulmonary parameters were monitored for a period of 30 minutes. Cardiac index was 104 +/- 15 mL/kg/min in the enoximone group, 72 +/- 13 mL/kg/min in the epinephrine group, and 63 +/- 10 mL/kg/min in the control group (P < .05 enoximone versus control and epinephrine). Right ventricular end systolic volume was 18 +/- 3, 27 +/- 4, and 29 +/- 6 mL in the enoximone, epinephrine, and control groups (P < .05 enoximone versus control and epinephrine). There were no differences in mea...Continue Reading

References

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