Cardiovascular effects of moderate normovolaemic haemodilution during enflurane-nitrous oxide anaesthesia in man

Acta Anaesthesiologica Scandinavica
P Van der LindenJ L Vincent

Abstract

The cardiovascular effects of mild normovolaemic haemodilution during enflurane-nitrous oxide anaesthesia were studied in 20 patients with normal cardiac function before, during and after total hip replacement. After induction of anaesthesia, patients were randomly allocated to one control group (C), or one haemodiluted group (H) where Hct was decreased to 30% by replacement of blood volume by an identical volume of hydroxyethyl starch 200/05. Each patient was monitored with a pulmonary artery catheter allowing the measurement of right ventricular ejection fraction. During haemodilution, stroke index and right ventricular end-diastolic volume index increased from 33.1 +/- 7.9 to 39.3 +/- 7.1 ml.M-2 and from 73.8 +/- 20.3 to 94.9 +/- 18.5 ml.M-2 respectively (mean +/- s.d., both P < 0.05). However, heart rate decreased so that cardiac index did not change. O2 delivery decreased significantly (from 389 +/- 70 to 311 +/- 63 ml.min-1.m-2; P < 0.05), but was not different to the control group. O2 consumption was maintained by an increase in O2 extraction. During the surgical procedure, cardiac index was higher in the haemodiluted group than in the control group, so that O2 delivery was similar in the two groups. O2 consumption tende...Continue Reading

References

May 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J D HatcherD B Jennings
May 1, 1978·The Journal of Bone and Joint Surgery. British Volume·G Du ToitR Gillespie
Aug 1, 1976·The American Journal of Physiology·W N Durán, E M Renkin
Nov 1, 1976·Chest·M M ShermanR L Berger
Sep 1, 1975·Journal of Applied Physiology·N O Fowler, J C Holmes
Sep 1, 1990·Indian Journal of Pediatrics·S Nath, D Vidyasagar
Sep 1, 1990·Anesthesiology·A ViitanenJ Heinonen
Feb 1, 1987·Clinical Pharmacokinetics·U Klotz, H Kroemer
Jun 1, 1989·Journal of Cardiothoracic Anesthesia·P Van der LindenJ L Vincent
Jan 1, 1988·Acta Anaesthesiologica Scandinavica. Supplementum·K Messmer
Jan 1, 1988·Acta Anaesthesiologica Scandinavica. Supplementum·B Lisander
May 1, 1986·Acta Anaesthesiologica Scandinavica·H Zetterström, L Wiklund
Jan 1, 1985·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·R Vara-Thorbeck, J A Guerrero-Fernandez Marcote
Jan 1, 1974·Journal of Applied Physiology·J A RodriguezE Rapaport
Mar 1, 1969·The American Journal of Physiology·J F MurrayE Rapaport
Jan 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C K Chapler, S M Cain
Nov 1, 1982·Acta Physiologica Scandinavica·E A RichterH Galbo
Oct 1, 1981·Acta Anaesthesiologica Scandinavica·B Roseberg, K Wulff
Nov 1, 1983·Anesthesia and Analgesia·I KissinJ G Reves
Mar 1, 1983·Anesthesiology·J B Gross
Jul 1, 1961·Anesthesiology·J W ECKSTEINJ M McCAMMOND

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Citations

Oct 3, 2002·Anesthesiology·Richard B Weiskopf
Aug 12, 1998·Acta Anaesthesiologica Scandinavica·P Hobisch-HagenJ Mair
Mar 23, 2005·Anesthesia and Analgesia·Denise Tabacchi FantoniJosé Otávio Costa Auler
Sep 16, 2000·Chest·G S YalavattiJ L Vincent
Apr 24, 2004·Transfusion·Jodi B SegalEliseo Guallar
Feb 1, 2003·Transfusion·Richard B WeiskopfPearl Toy
Dec 3, 2014·Journal of Cardiothoracic and Vascular Anesthesia·George J Crystal
Oct 23, 2001·Vascular Surgery·T BombardiniG C Caroli
Jan 26, 1999·Clinical Orthopaedics and Related Research·T G Monk, L T Goodnough

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