PMID: 6983316Dec 1, 1982Paper

Cardiovascular effects of nalbuphine in patients with coronary or valvular heart disease

Anesthesiology
C L LakeM R Magruder

Abstract

Although the hemodynamic changes produced by small doses of nalbuphine given to patients with cardiac disease are minimal, the cardiovascular effects of large doses which have been used as supplements for general anesthesia have not been investigated. Cardiovascular variables were measured after incremental doses of nalbuphine, up to 2 or 3 mg/kg in fourteen patients with coronary artery disease with normal left ventricular function and in seven patients with mitral valve disease. No significant changes in cardiac index, stroke work index, mean arterial pressure, pulmonary diastolic or wedge pressure, heart rate, or central venous pressure occurred in the preoperative period. However, nalbuphine alone did not produce surgical anesthesia and the addition of diazepam, nitrous oxide, or halothane was required in all patients. The addition of halothane coupled with surgical stimulation significantly decreased cardiac and stroke indices, increased mean arterial and pulmonary wedge pressures, and increased systemic vascular resistance in patients with coronary artery disease. In patients with mitral valve disease, following surgical incision, there were small but significant decreases in cardiac index and left ventricular stoke work ...Continue Reading

Associated Clinical Trials

Citations

Sep 1, 1993·Der Schmerz·H Bierbach
Sep 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E HewE Hew-Sang
Jul 1, 1987·Journal of the Royal Society of Medicine·R A GreenbaumP D Mason
Jan 1, 1997·Fundamental & Clinical Pharmacology·G BessardP Devillier
Nov 8, 2002·Emergency Medicine Journal : EMJ·M WoollardN Vetter
Jun 1, 1988·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·E A DolanN Gleason
Nov 1, 1988·The American Journal of Emergency Medicine·J K SteneB Burns
Apr 1, 1989·International Journal of Cardiology·T G Trouton, A A Adgey
Jun 1, 1984·Acta Anaesthesiologica Scandinavica·C L LakeM R Magruder
Jan 1, 1985·Oral Surgery, Oral Medicine, and Oral Pathology·T J Pallasch, C J Gill
Jan 1, 1992·Annales Françaises D'anesthèsie Et De Rèanimation·J F Arnould, M Pinaud
Apr 14, 2018·The American Journal of Hospice & Palliative Care·Mellar P DavisCarlos Fernandez
Oct 30, 2019·Journal of Palliative Medicine·Fay MathaiMellar Davis
May 1, 1986·Anaesthesia and Intensive Care·P J SlatteryR A Couch
Mar 23, 2021·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Song WenLiu-Lin Xiong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
R F Scott
Drug and Alcohol Dependence
W K SchmidtV G Vernier
Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
E HewE Hew-Sang
© 2021 Meta ULC. All rights reserved