Cardiovascular effects of nitric oxide in the brain stem nuclei of rats

Hypertension
C J TsengM H Yen

Abstract

Nitric oxide, synthesized from the semiessential amino acid L-arginine by nitric oxide synthase, is a remarkable regulatory molecule and plays an important role in physiological functions. However, the physiological role of nitric oxide in cardiovascular regulation by the central nervous system is not well understood. In this study we investigated the cardiovascular effects of nitric oxide in the lateral ventricle, nucleus tractus solitarii, area postrema, and rostral ventrolateral medulla in urethane-anesthetized male Sprague-Dawley rats. Microinjection of NG-monomethyl-L-arginine, a nitric oxide synthase inhibitor, into the cerebral ventricle of rats elicited a dose-dependent increase in blood pressure and heart rate. This suggests that nitric oxide may be involved in central cardiovascular regulation. Unilateral microinjection (60 nL) of L-arginine (1 to 100 nmol) into the nucleus tractus solitarii and rostral ventrolateral medulla produced prominent dose-related depressor and bradycardic effects and reduced renal sympathetic nerve activity. However, L-arginine had no significant cardiovascular effects in the area postrema. In addition, 4 to 6 hours after intravenous injection of bacterial endotoxin-lipopolysaccharide (10 mg...Continue Reading

References

Sep 1, 1992·Journal of Neurochemistry·M L Simmons, S Murphy
Oct 28, 1991·Neuroscience Letters·L N ShapovalL S Pobegailo
Jul 31, 1990·Biochemical and Biophysical Research Communications·L J IgnarroJ Rajfer
May 1, 1990·Hypertension·S M GardinerS Moncada
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R G KilbournR F Lodato
Jul 5, 1990·The New England Journal of Medicine·J A PanzaS E Epstein
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I SakumaR Levi
Oct 1, 1987·Nature·T M GriffithK T Evans
Jan 1, 1994·Annual Review of Biochemistry·D S Bredt, S H Snyder

❮ Previous
Next ❯

Citations

Apr 25, 2003·Journal of Biomedical Science·Alice Y W ChangSamuel H H Chan
Oct 12, 2010·World Journal of Urology·Amira M Senbel
Aug 23, 2006·Neurosurgical Review·Peter Kan, William T Couldwell
May 11, 2002·Current Hypertension Reports·Vito M Campese, Ewa Krol
Dec 7, 2006·Current Hypertension Reports·Terry N Thrasher
Mar 30, 2005·Autonomic Neuroscience : Basic & Clinical·Rong MaWei Wang
Nov 10, 2001·Brain Research·M L WeissJ Huang
Jul 17, 1998·Brain Research·K MatsumuraM Fujishima
Oct 26, 2000·European Journal of Pharmacology·H C LinC J Tseng
Jul 17, 1999·Brain Research. Brain Research Reviews·T L Krukoff
Oct 23, 1997·Brain Research. Molecular Brain Research·D Plochocka-Zulinska, T L Krukoff
Mar 29, 2003·Journal of Chemical Neuroanatomy·Hung-Ming ChangJeng-Yung Shieh
Apr 18, 2008·International Journal of Impotence Research·A M Senbel, T Mostafa
Feb 24, 2001·Clinical and Experimental Pharmacology & Physiology·S Y ChenC Y Chai
Aug 4, 2005·Journal of Toxicology and Environmental Health. Part a·Yu-Mei HsuehChien-Jen Chen
Dec 25, 2002·Journal of Cardiovascular Pharmacology·Fengyang HuangEnrique Hong
Feb 12, 2004·Journal of Cardiovascular Pharmacology·Yoshitaka HirookaAkira Takeshita
Oct 13, 2010·Anti-cancer Drugs·Guadalupe Aparicio-GallegoLuis M Antón-Aparicio
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Claire E SearsBarbara Casadei
Jul 23, 1998·Clinical and Experimental Pharmacology & Physiology·T L Krukoff
Mar 11, 2004·Clinical and Experimental Pharmacology & Physiology·Wun-Chin Wu, Chok-Yung Chai
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Rohit RamchandraSimon C Malpas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.