Cardiovascular effects of pimobendan in healthy mature horses

Equine Veterinary Journal
T AfonsoA E Coleman

Abstract

Pimobendan is an inodilator used in dogs for the management of heart failure due to myxomatous valve disease or dilated cardiomyopathy. The lack of data regarding the effects of pimobendan in horses prevents the rational use of this drug. To determine the cardiovascular effects of pimobendan in healthy mature horses. Randomised experimental study. Five horses were fasted overnight prior to receiving i.v. pimobendan (0.25 mg/kg bwt), intragastric (i.g.) pimobendan (0.25 mg/kg bwt) or i.g. placebo with a washout period of one week between each administration. Horses were instrumented for the measurement of right ventricular (RV) minimum pressure, RV maximum pressure, RV end diastolic pressure, and maximum rate of increase and decrease in RV pressure before and 0.5, 1, 2, 4, and 8 h after drug administration. Arterial blood pressure, central venous pressure, cardiac output and heart rate were measured at the same time points. Data were expressed as a maximum percentage of change over baseline values. There were no adverse effects associated with administration of pimobendan. The percentage increase in heart rate was significantly greater for horses given pimobendan i.g. (33 ± 4%) and i.v. (36 ± 14%) than for those given a placebo ...Continue Reading

References

Sep 1, 1976·The Journal of Clinical Investigation·J L WeissM L Weisfeldt
Sep 1, 1992·Journal of Veterinary Pharmacology and Therapeutics·J M EnsinkA G Vulto
Jan 1, 1989·Journal of Cardiovascular Pharmacology·J C van Meel, W Diederen
Nov 1, 1996·Journal of Veterinary Internal Medicine·T L GrubbL E Davis
Mar 3, 1999·Journal of Veterinary Internal Medicine·P ConstableD Sisson
May 23, 2002·Journal of the American Veterinary Medical Association·Jennifer L DavisBabetta A Breuhaus
Jun 4, 2002·Journal of Veterinary Internal Medicine·Virginia Luis FuentesClaus Justus
Oct 31, 2002·Equine Veterinary Journal. Supplement·M M DurandoE K Birks
Jan 1, 1962·The Journal of Clinical Investigation·W L GLEASON, E BRAUNWALD
Jul 1, 1963·The American Journal of Physiology·A G WALLACEJ H MITCHELL
Mar 26, 2005·The Journal of Small Animal Practice·P J SmithJ Dukes-McEwan
Feb 4, 2006·American Journal of Veterinary Research·Jennifer L DavisMark G Papich
Jul 11, 2006·Journal of the American Animal Hospital Association·Christophe W LombardClaudio M Bussadori
Sep 29, 2009·Journal of Veterinary Internal Medicine·C AtkinsR Stepien
Aug 30, 2012·Journal of Veterinary Emergency and Critical Care·Kimberly L Boyle, Elizabeth Leech
Oct 12, 2013·Journal of Veterinary Internal Medicine·A A LerouxH Amory

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Citations

Jun 23, 2016·The Veterinary Clinics of North America. Equine Practice·Celia M Marr

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