Cardiovascular effects of romifidine in dogs

American Journal of Veterinary Research
B H Pypendop, J P Verstegen

Abstract

To characterize the cardiovascular effects of romifidine at doses ranging from 5 to 100 microg/kg of body weight, IV. 25 clinically normal male Beagles. Romifidine was administered IV at a dose of 5, 10, 25, 50, or 100 microg/kg (n = 5/group). Heart rate, arterial pressure, central venous pressure, mean pulmonary arterial pressure, pulmonary capillary wedge pressure, body temperature, cardiac output, and PCV were measured immediately prior to and at selected times after romifidine administration. Cardiac index, stroke index, rate-pressure product, systemic and pulmonary vascular resistance indices, and left and right ventricular stroke work indices were calculated. Degree of sedation was assessed by an observer who was blinded to the dose administered. Romifidine induced a decrease in heart rate, pulmonary arterial pressure, rate-pressure product, cardiac index, and right ventricular stroke work index and an increase in central venous pressure, pulmonary capillary wedge pressure, and systemic vascular resistance index. In dogs given romifidine at a dose of 25, 50, or 100 microg/kg, an initial increase followed by a prolonged decrease in arterial pressure was observed. Arterial pressure immediately decreased in dogs given romifi...Continue Reading

References

Jan 1, 1996·The Journal of Small Animal Practice·G C EnglandR Hammond
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Apr 1, 1997·The Journal of Small Animal Practice·G C England, R Hammond
Dec 9, 1998·Veterinary Surgery : VS·B H Pypendop, J P Verstegen

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Citations

Dec 30, 2006·Veterinary Research Communications·S SuwanwipatN Chaiyabutr
Mar 4, 2009·Journal of Feline Medicine and Surgery·Eduardo R MonteiroLuísa Z Furlan
Sep 13, 2002·American Journal of Veterinary Research·William W Muir, Jennifer E Gadawski
Aug 20, 2002·Journal of the American Veterinary Medical Association·André L SelmiConcepta McManus
Oct 7, 2005·Journal of Veterinary Pharmacology and Therapeutics·R J Gómez-VillamandosJ M Santisteban
May 28, 2009·Veterinary Anaesthesia and Analgesia·Eliseo BeldaMarta Soler
Oct 24, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·R J Gómez-VillamandosJ M Santisteban
Jun 21, 2008·Veterinary Anaesthesia and Analgesia·Eduardo R MonteiroCarlos M Bettini
Jun 21, 2013·Veterinary Anaesthesia and Analgesia·Rafael J Gómez-VillamandosMaría M Granados
Apr 16, 2011·Veterinary Anaesthesia and Analgesia·Rocío NavarreteRafael J Gómez-Villamandos
Jul 20, 2010·Veterinary Anaesthesia and Analgesia·Miguel Gozalo MarcillaFrank Gasthuys
Mar 17, 2010·Veterinary Anaesthesia and Analgesia·Véronique Martin-BouyerIngeborgh Polis
Jul 23, 2004·Veterinary Anaesthesia and Analgesia·André L SelmiBruno T Lins
Jul 23, 2004·Veterinary Anaesthesia and Analgesia·André L SelmiBruno T Lins
Aug 20, 2003·Veterinary Anaesthesia and Analgesia·Melissa D SinclairWayne N McDonell
Jan 30, 2014·Acta Cirúrgica Brasileira·Renata Navarro CassuPaula Denise de Oliveira Martins
Sep 19, 2002·The Journal of Veterinary Medical Science·Kazuyuki SuzukiRyuji Asano
Jan 1, 2002·Veterinary Anaesthesia and Analgesia·Melissa D SinclairGlenn Pettifer

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