PMID: 2446079Jan 1, 1987

Cardiovascular effects of serotonin

Journal of Cardiovascular Pharmacology
P M Vanhoutte

Abstract

The major target for circulating serotonin (released from aggregating platelets) appears to be the blood vessel wall (although little evidence is available), suggesting a role for the monoamine in controlling cardiac function. In cerebral blood vessels, serotonergic neurons are present, implying a potential serotonergic neurogenic control. Serotonin causes contraction of most large arteries and veins; it also causes contraction of venules. This is due mainly to direct activation of vascular smooth muscle, although amplification of the response to other endogenous vasoconstrictors (e.g., angiotensin II and norepinephrine) as well as facilitated release of norepinephrine may contribute. In peripheral blood vessels, the receptors mediating the contractions evoked by serotonin belong mainly to the 5-HT2-serotonergic subtype; in the coronary and cerebral arteries, this need not be the case. Vasodilator responses to serotonin are seen mainly at the arteriolar level, but they can also be observed in larger blood vessels. They can be caused by the release of other endogenous vasodilators (e.g., vasoactive intestinal polypeptide), direct relaxation of vascular smooth muscle, inhibition of adrenergic neurotransmission, or production of e...Continue Reading

Citations

Nov 1, 2012·Journal of Veterinary Emergency and Critical Care·Danielle E ThomasLynn R Hovda
Jan 28, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T OkamotoT K Smith
Oct 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·M E Comunale, S A Neilly
May 4, 2004·Trends in Molecular Medicine·Francine CôtéGuilan Vodjdani
Apr 1, 1989·British Journal of Clinical Pharmacology·A K ScottJ C Petrie
Jun 1, 1992·Pharmacology & Toxicology·P A van ZwietenP van Brummelen

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Cardiovascular System
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