Cardiovascular effects of the novel Ca2+-sensitiser EMD 57033 in pigs at rest and during treadmill exercise

British Journal of Pharmacology
R StubenitskyD J Duncker

Abstract

1. To date no study has described the cardiovascular effects of increased myofilament Ca2+ responsiveness in awake animals both under resting conditions and during treadmill exercise. In the present study we therefore investigated the systemic, pulmonary and coronary haemodynamic actions of the Ca2+ sensitizer EMD 57033 in 16 chronically instrumented awake pigs at rest and during treadmill exercise, and compared these to the haemodynamic actions of the Ca2+ sensitizer/phosphodiesterase inhibitor pimobendan. 2. Under resting conditions EMD 57033 (0.2, 0.4 and 0.8 mg kg(-1) min(-1), i.v.) produced dose-dependent increases in LVdP/dt(max) (up to 65+/-17% (mean+/-s.e.mean), P < or = 0.05) and stroke volume (up to 20+/-3%, P < or = 0.05), with an increase in heart rate only after the highest dose (22+/-5%, P < or = 0.05), while mean aortic blood pressure and LVdP/dt(min) were not altered. EMD 57033 had also no effect on pulmonary vascular resistance, but produced dose-dependent decreases in systemic vascular resistance (32+/-4%, P < or = 0.05), and coronary vascular resistance (44+/-2%, P < or = 0.05). These effects were essentially unchanged when animals were pretreated with non-selective beta-adrenoceptor blockade, indicating that...Continue Reading

References

Oct 1, 1989·Journal of Cardiovascular Pharmacology·W J van der GiessenP D Verdouw
Dec 1, 1986·European Heart Journal·J M HartogP D Verdouw
Feb 1, 1986·The American Journal of the Medical Sciences·N C ManzioneI Sternlieb
Jul 22, 1982·The New England Journal of Medicine·M R BristowE B Stinson
Sep 1, 1981·Pflügers Archiv : European journal of physiology·J W HerzigG Wölffle
Oct 1, 1994·Journal of Cardiovascular Pharmacology·R NankervisL Brown
Mar 1, 1995·Basic Research in Cardiology·E Bassenge
Jan 1, 1994·European Journal of Clinical Pharmacology·J LillebergM S Nieminen
Mar 1, 1993·Journal of Molecular and Cellular Cardiology·T GrossJ Daut
Jan 12, 1996·The Journal of Biological Chemistry·B S Pan, R G Johnson
Apr 12, 1996·Molecular and Cellular Biochemistry·U RavensS E Harding

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Citations

Dec 28, 1999·European Journal of Pharmacology·L K SoeiP D Verdouw
Oct 22, 2013·Pharmacology & Therapeutics·Nima Milani-Nejad, Paul M L Janssen
Jul 13, 2000·Journal of Cardiovascular Pharmacology·B K SlinkerK B Campbell
Feb 7, 2002·Cardiovascular Drug Reviews·M EndohM Mineshima
Nov 14, 1998·The American Journal of Physiology·D J DunckerP D Verdouw

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