PMID: 9192541Apr 1, 1997Paper

Cardiovascular effects of tricyclic antidepressants in childhood asthma: a case series and review

Journal of Child and Adolescent Psychopharmacology
M Z WamboldtT A Roesler

Abstract

Children with asthma frequently have significant anxiety and depression that interfere with treatment outcome. Although the use of antidepressants may be helpful, in the one published study of antidepressant use in pediatric asthma, significant side effects necessitated discontinuance; these side effects were increased motor activity, impulsive behavior, insomnia, postural hypotension, premature auricular contractions, diastolic hypertension, and generalized seizure. The objective of this retrospective chart review was to examine whether antidepressants could be tolerated and administered safely to children on asthma medications. Forty pediatric inpatients (mean age 13.3 years, range 7-19) with varying levels of asthma severity (5 mild, 11 moderate, 24 severe) and an average duration of asthma treatment of 10.0 years were administered antidepressants while also taking an average of 5 medications for asthma (range 2-7). Ten of the patients had an additional comorbid medical diagnosis. There were 17 children diagnosed with a primary affective disorder; 7 with a primary anxiety disorder; and 16 with both an affective and anxiety disorder. Thirty-six children ultimately were continued on an antidepressant: 13 on desipramine, 9 on n...Continue Reading

Associated Clinical Trials

References

Feb 1, 1992·Pediatric Pulmonology·A K KamadaS J Szefler
Oct 1, 1985·The Journal of Allergy and Clinical Immunology·R PauwelsC G Persson

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Citations

Apr 23, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Tasanee R WalshDarren A DeWalt
Nov 18, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Doron GothelfIsaac Yaniv
Aug 16, 2000·Current Opinion in Pediatrics·N Galil
Sep 16, 2000·The American Journal of Forensic Medicine and Pathology·H J CarsonN E Lueck
Aug 31, 2006·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S GuptaI Mitchell

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