PMID: 7034659Feb 1, 1982Paper

Cardiovascular effects of ventilation with positive expiratory airway pressure

Annals of Surgery
P K SmithJ S Rankin

Abstract

The broad clinical application of positive and expiratory pressure (PEEP) in the treatment of a variety of respiratory disorders has led to the observation that positive airway pressure can result in cardiac dysfunction. Recent attempts to integrate and extend the results of past research have led to diverse explanations of the overall cardiopulmonary effects of PEEP. This review summarizes previous work in the field and attempts to explain the basis of the divergent conclusions of previous investigators. Data are presented from several experimental models, as well as studies in postoperative patients to formulate an overall analysis of the influence of airway pressure on the central circulation. It appears that the effects of PEEP are primarily mechanical and are mediated through a combination of right ventricular preload limitation and outflow obstruction. Both effects are additive in limiting left ventricular preload and can be ameliorated by volume loading in the absence of significant right ventricular or pulmonary vascular disease. Neural, humoral and ventricular interactive forces appear to be insignificant under most circumstances. The clinical implications of these advances in the current understanding of PEEP are revi...Continue Reading

References

Feb 1, 1978·Annals of Surgery·J MannyH B Hechtman
Sep 1, 1976·Circulation Research·J S RankinR W Anderson
Jul 1, 1977·Circulation Research·J S RankinR W Anderson
Sep 1, 1966·Circulation Research·W R MilnorJ D Bargainer
Feb 12, 1981·The New England Journal of Medicine·F JardinJ P Bourdarias
Feb 12, 1981·The New England Journal of Medicine·S S CassidyR L Johnson

❮ Previous
Next ❯

Citations

Jul 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S EliaD Lappas
May 1, 1993·Acta Anaesthesiologica Scandinavica·Y Fujita
Mar 4, 2009·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Michael L Cheatham
Dec 1, 1991·The American Journal of the Medical Sciences·J S Parker, B P deBoisblanc
Oct 1, 1985·Chest·J G TittleyP R McLaughlin
Apr 1, 1994·Burns : Journal of the International Society for Burn Injuries·G F NiemanT S Hakim
Jan 1, 2007·Acta Clinica Belgica·M L Cheatham, M L N G Malbrain
Oct 27, 2016·Echocardiography·Antonello D'AndreaEduardo Bossone
May 1, 1989·Circulation Research·J C Gilbert, S A Glantz
Mar 25, 2005·Journal of the American Veterinary Medical Association·Justine A LeeLesley G King
Sep 5, 2002·Critical Care Nursing Quarterly·Mara M BaunJoyce A Rogge
Nov 1, 1987·The Annals of Thoracic Surgery·W G Wolfe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.