Cardiovascular effects produced by R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin in the preoptic area of conscious rats

European Journal of Pharmacology
A SzabóR H Alper

Abstract

Experiments were designed to test the hypothesis that activation of forebrain 5-HT1A receptors elicits cardiovascular responses. The microinjection of R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin [(+)-8-OH-DPAT], a selective 5-HT1A receptor agonist, in the preoptic area of conscious rats increased blood pressure and heart rate at doses of 0.2-20 nmol; lower doses (0.002 and 0.02 nmol) were ineffective. The concomitant administration of methiothepin, a non-selective 5-HT receptor antagonist, into the preoptic area attenuated the responses. In addition, the tachycardia elicited by (+)-8-OH-DPAT was abolished by the peripheral beta-adrenoceptor antagonist sotalol, but not by atropine methyl nitrate. Finally, the tachycardia, but not the hypertension, was also produced by (+)-8-OH-DPAT in urethane-anesthetized rats. These results suggest that activation of 5-HT1A receptors in the preoptic area or an adjacent region of the forebrain produces: (1) an increase in heart rate consistent with sympathoadrenal activation; and (2) an increase in blood pressure which might be the result of sympathoexcitation or secondary to behavioral arousal.

References

Jul 30, 1976·Brain Research·J F Smits, H A Struyker-Boudier
Feb 1, 1992·Journal of Neuroscience Methods·T SeguraJ R Haywood
Jul 1, 1991·Journal of Neuroscience Methods·L RiboniH Núñez-Durán
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
May 1, 1963·Journal of Applied Physiology·R A MitchellJ W Severinghaus

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Citations

Nov 3, 2004·Brain Research·Hilda Silva FerreiraJosmara Bartolomei Fregoneze
Nov 29, 2005·Respiratory Physiology & Neurobiology·Luciane H GargaglioniLuiz G S Branco
Jan 7, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick Osei-Owusu, Karie Scrogin
Apr 16, 2005·Clinical Science·Stephanie W Watts

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