Abstract
The aim of this study was to examine ethnicity-specific associations between type 2 diabetes mellitus and the risk of a cardiovascular disease (CVD) event as well as risk of specific CVD phenotypes in England. We obtained data from the Clinical Practice Research Datalink for adults with and without type 2 diabetes mellitus diagnosed 2000-2006. The outcome was the first CVD event during 2007-2017 and the following components: aortic aneurysm, cerebrovascular accidents, heart failure, myocardial infarction, peripheral vascular disease and other CVD-related conditions. Flexible parametric survival models were used to estimate ethnicity-specific adjusted hazard ratios. A total of 734,543 people with and without type 2 diabetes mellitus (29,847; 4.1%) were included; most were of white ethnicity (93.0% with and 92.3% without type 2 diabetes mellitus) followed by South Asian (3.2 and 4.6%). During a median follow-up period of 11.0 years, 67,218 events occurred (6,156 in individuals with type 2 diabetes mellitus). Type 2 diabetes mellitus was associated with a small increase in CVD events (adjusted hazard ratio 1.06, 95% confidence interval 1.02-1.09) in individuals of white ethnicity; whereas the adjusted hazard ratios were considerab...Continue Reading
References
Nov 9, 2000·Lancet·S S AnandM McQueen
Nov 15, 2000·Journal of Public Health Medicine·R Bhopal
Aug 11, 2006·Statistics in Medicine·Melania Pintilie
Jul 7, 2007·BMC Public Health·C M FischbacherD Knowles
Aug 11, 2007·Heart·S HardingA Teyhan
Feb 7, 2008·International Journal of Cardiology·Konstantinos TziomalosAlexander M Seifalian
Jun 13, 2008·Public Health Nutrition·Chi Pang WenMichael P Eriksen
Feb 11, 2009·The British Journal of Nutrition·Elaine C RushLindsay D Plank
Jun 12, 2009·Lancet·Adam G TabákDaniel R Witte
Jul 9, 2010·Lancet·UNKNOWN Emerging Risk Factors CollaborationJ Danesh
Oct 6, 2010·Circulation·Nadia A KhanHude Quan
Sep 6, 2012·Circulation·Jean-Pierre Després
Jan 30, 2014·BMJ : British Medical Journal·Yu ChenJohn D Potter
Dec 4, 2014·The Lancet. Diabetes & Endocrinology·Anoop Dinesh ShahHarry Hemingway
Feb 13, 2015·Heart·Nitin N GholapIain B Squire
Jun 8, 2015·International Journal of Epidemiology·Emily HerrettLiam Smeeth
Aug 22, 2015·Circulation·Tobin M AbrahamCaroline S Fox
Aug 28, 2015·Lancet·Anoop Dinesh ShahHarry Hemingway
Oct 23, 2015·The Lancet. Diabetes & Endocrinology·Naveed Sattar, Jason M R Gill
Oct 29, 2015·American Journal of Epidemiology·Jan Vandenbroucke, Neil Pearce
Oct 29, 2015·American Journal of Epidemiology·Jan Vandenbroucke, Neil Pearce
Dec 22, 2016·Diabetes Care·Alison K WrightDarren M Ashcroft
Jan 21, 2017·Journal of the American College of Cardiology·Markus C ElzeStuart J Pocock
Feb 18, 2017·Diabetes, Obesity & Metabolism·Sanjoy K PaulKamlesh Khunti
Aug 16, 2018·The New England Journal of Medicine·Aidin RawshaniSoffia Gudbjörnsdottir
Sep 2, 2018·Diabetologia·Jessica L HardingEdward W Gregg
Oct 6, 2018·The Lancet. Diabetes & Endocrinology·Andrew P HillsAnoop Misra
Nov 21, 2018·Acta Diabetologica·Lorenzo M VetroneKamlesh Khunti