Cardiovascular events as a function of serum bilirubin levels in a large, statin-treated cohort

Laura J HorsfallIrene Petersen


Serum bilirubin is an endogenous antioxidant that is routinely measured before a statin is prescribed primarily to assess liver function, but the association with cardiovascular disease (CVD) in this population has not been explored. We identified patients from a United Kingdom primary care database (The Health Improvement Network) with measurements of serum total bilirubin levels recorded 3 months before the first statin treatment between January 1, 2000, and December 31, 2010, and no history of liver disease or CVD. In total, 130 052 patients met the inclusion criteria, and after a median follow-up of 43 months, there were 7850 CVD events. In men, the incidence of CVD in the lowest decile category of bilirubin (1-6 μmol/L [0.06-0.35 mg/dL]) was 215 per 10 000 person-years compared with 163 per 10 000 person-years in the highest decile (19-40 μmol/L [1.1-2.3 mg/dL]). Similar differences were seen for women. After conventional CVD risk factors were accounted for, the associations with bilirubin were nonlinear (L shaped), and the models predicted that, compared with patients with a bilirubin level of 10 μmol/L (0.6 mg/dL), those with a similar CVD risk profile but a bilirubin level of 5 μmol/L (0.3 mg/dL) had an 18% (95% confide...Continue Reading


Jun 1, 1975·Journal of Medical Genetics·D Owens, J Evans
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Nov 2, 1995·The New England Journal of Medicine·P J BosmaR P Oude Elferink
Aug 6, 1994·Health Libraries Review·N Booth
May 18, 2001·The American Journal of Cardiology·L DjousséR C Ellison
Apr 16, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Thomayant PrueksaritanontThomas A Baillie
Apr 24, 2003·Experimental Biology and Medicine·Ladislav Novotný, Libor Vítek
Oct 23, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Keiichi KawamuraYukio Maruyama
Sep 13, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Judit K Sarady-AndrewsLeo E Otterbein
Mar 28, 2006·Biochemical and Biophysical Research Communications·Mark HsuDavid K Stevenson
Sep 29, 2007·Canadian Journal of Physiology and Pharmacology·Lucie MuchovaDavid K Stevenson
Dec 10, 2008·Pharmacoepidemiology and Drug Safety·Andrew MaguireMary Thompson
Mar 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Thomas W SedlakSolomon H Snyder
May 21, 2009·Pharmacoepidemiology and Drug Safety·Shreya Davé, Irene Petersen
Jun 11, 2009·JAMA : the Journal of the American Medical Association·George Thanassoulis, Christopher J O'Donnell
Oct 2, 2009·Clinical Pharmacology and Therapeutics·S RiedmaierU M Zanger
Mar 6, 2010·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Nada F KhanPeter W Rose
Jun 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhe-Yi HuCheng Guo
Aug 7, 2010·Southern Medical Journal·Koichiro OkuharaMasao Yoshizumi
Feb 5, 2011·Circulation. Cardiovascular Genetics·Christopher D AndersonJonathan Rosand
Mar 18, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Ying-Hwa ChenDer-Cherng Tarng
May 17, 2011·Journal of Epidemiology and Community Health·Lisa SzatkowskiTim Coleman
Jun 28, 2011·Journal of Lipid Research·Pernette R W de Sauvage NoltingUNKNOWN ExPRESS study group
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