Cardiovascular function during rest and exercise in patients with sickle-cell anemia and coexisting alpha thalassemia-2

American Journal of Hematology
D S BradenP F Milner

Abstract

Cardiac function was measured at rest and during exercise in 9 patients with sickle-cell anemia (SS) and coexisting homozygous alpha thalassemia-2 (alpha thal-2). Results were compared with 18 sickle cell patients with normal alpha globin genes, who were matched to the study group by age, gender, and size, and to published normal values. SS alpha thal-2 patients were less anemic: 9.9 +/- 1.0 vs 8.2 +/- 1.2 gm/dl for SS alone (P<.05). Left ventricular dimensions were normal in SS alpha thal-2 (4.9 +/- 0.7 cm), but increased in SS (5.4 +/- 0.7, cm P=.05) (normal range, 3.7-5.6 cm). Left ventricular wall thickness was, however, dramatically increased in the SS alpha thal-2 patients (free wall, 1.8 +/- 0.6 cm; septum, 1.6 +/- 0.4 cm), though SS controls had normal wall thickness (free wall, 1.0 +/- 0.2 cm; septum, 1.0 +/- 0.2 cm, P<.001) (normal range, 0.6-1.1 cm). At rest, Doppler indices of systolic function were not significantly different between sickle groups and normal values. SS alpha thal-2 patients did have abnormal diastolic filling at rest, as evidenced by a reduced ratio of early/late diastolic filling, 1.4 +/- 0.3 vs. 2.0 +/- 0.5 for SS controls (P<.01), and 1.8 +/- 0.4 for normals. An analysis of covariance suggested ...Continue Reading

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Citations

May 7, 2002·American Journal of Respiratory and Critical Care Medicine·Leigh A CallahanBernard Gutin
Aug 28, 2012·Chest·Rifat A ChaudrySuzanne Crowley
May 10, 2005·British Journal of Haematology·M H Steinberg
May 7, 2014·American Journal of Hematology·Eduard J van BeersPaul Bresser
Jan 30, 2007·Journal of the American College of Cardiology·Vandana SachdevMark T Gladwin
Sep 21, 2006·American Journal of Hematology·Hisham MoheebMahmoud S El-Sayed
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Related Concepts

Anemia, Sickle Cell
Diastolic Blood Pressure
Coronary Circulation
Diastole
2D Echocardiography
Cardiopulmonary Exercise Test
Heart
Hemodynamics
Systole
2D Doppler Echocardiography

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