Cardiovascular function of a glutamatergic projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarius in the rat.

Neuroscience
Tetsuya KawabeH N Sapru

Abstract

Experiments were done in urethane-anesthetized, barodenervated, male Wistar rats. Chemical stimulation of the hypothalamic paraventricular nucleus (PVN) by unilateral microinjections of N-methyl-D-aspartic acid (NMDA) elicited increases in mean arterial pressure (MAP) and greater splanchnic nerve activity (GSNA). The increases in the MAP and GSNA induced by chemical stimulation of the PVN were significantly exaggerated by bilateral microinjections of D(-)-2-amino-7-phosphono-heptanoic acid (D-AP7) and 2,3-dioxo-6-nitro-1,2,3,4-tetrahydro-benzo[f]quinoxaline-7-sulfonamide disodium (NBQX) (ionotropic glutamate receptor antagonists) into the medial subnucleus of the nucleus tractus solitarius (mNTS). These results were confirmed by single unit recordings; i.e. excitation of mNTS barosensitive neurons caused by chemical stimulation of the ipsilateral PVN was blocked by application of D-AP7 and NBQX to these neurons. Bilateral microinjections of D-AP7 and NBQX into the mNTS elicited pressor responses which were significantly attenuated by inhibition of PVN neurons by bilateral microinjections of muscimol. Unilateral microinjections of fluorogold into the mNTS resulted in bilateral retrograde labeling of the PVN neurons. Unilateral m...Continue Reading

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Citations

Nov 16, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Vineet C Chitravanshi, Hreday N Sapru
Sep 2, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Takeshi NakamuraHreday N Sapru
Mar 20, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vineet C ChitravanshiHreday N Sapru
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christal G ColemanVirginia M Pickel
Mar 3, 2012·Neurochemical Research·ZeGang Ma, TianWei Liu
Dec 25, 2012·Autonomic Neuroscience : Basic & Clinical·Hreday N Sapru
Jun 28, 2011·The American Journal of Pathology·Alexandra Vranyac-TramoundanasIvan A Sammut
May 18, 2016·Scientific Reports·Stephanie C Tjen-A-LooiJohn C Longhurst
May 12, 2004·Peptides·Cinda J Helke, Jeanne L Seagard
May 21, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Vineet C ChitravanshiHreday N Sapru
Sep 6, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Morgayn I ReadIvan A Sammut
Sep 12, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian C RuyleEileen M Hasser
Nov 29, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Tetsuya KawabeHreday N Sapru
Sep 16, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Edmund CauleyDavid Mendelowitz
Apr 12, 2017·Frontiers in Neurology·Andrew A McCallBill J Yates
May 10, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Vineet C ChitravanshiHreday N Sapru
Oct 20, 2018·Neurobiology of Learning and Memory·Joe ArthursSteve Reilly
Jan 29, 2019·European Journal of Pharmacology·Yasunori UmemotoVineet C Chitravanshi
Jul 17, 2021·Antioxidants & Redox Signaling·Marialuisa Perrotta, Daniela Carnevale
Oct 23, 2021·The Journal of Physiology·Coty M CooperEric Beaumont

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