Abstract
Cardiovascular disease is a common comorbidity associated with an aging population. However, there is a unique group of individuals whose age-defying qualities are still being investigated. This retrospective chart review analyzed various cardiac and metabolic health parameters to characterize the prevalence of heart failure and metabolic derangements in individuals aged 90 years old or older in central Arkansas. Only 236 of the 291 patients in our study cohort had blood pressures recorded. Of these, 50% had systolic blood pressures ≥140 mmHg. Additionally, 77% had pulse pressures ≥50 mmHg. Of the 96 patients with BNP data, 44% had values ≥300 pg/mL. There was a slight positive correlation between aging and HDL cholesterol, while there was a negative correlation between aging and both total cholesterol and LDL cholesterol. A majority of our patients had both elevated systolic blood pressures and elevated pulse pressures. A majority also had high BNP values, indicative of some degree of heart failure. Additionally, atrial fibrillation was a common arrhythmia identified on EKG. However, these oldest of the old patients had fewer documented metabolic derangements. These findings lay important groundwork for further investigation i...Continue Reading
References
Dec 10, 1992·The New England Journal of Medicine·J Y Wei
Nov 1, 1994·Journal of Gerontology·P W WilsonW P Castelli
Nov 1, 1993·Metabolism: Clinical and Experimental·D J RaderH B Brewer
Apr 16, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G BaggioC Franceschi
Jul 16, 1999·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·R S SamuelJ Y Wei
Feb 24, 2001·Journal of the American Geriatrics Society·N BarzilaiJ D Sorkin
Aug 11, 2001·American Journal of Hypertension·J B KostisC R Lacy
Nov 24, 2004·Journal of Atherosclerosis and Thrombosis·Yasumichi Arai, Nobuyoshi Hirose
Apr 26, 2013·Circulation. Heart Failure·Paul A HeidenreichUNKNOWN Stroke Council
Feb 5, 2014·Journal of the American College of Cardiology·Andrew P AmbrosyMihai Gheorghiade
Nov 5, 2014·Hypertension·Zhongjie Sun
Feb 3, 2016·Ageing Research Reviews·Thomas W Buford
Apr 6, 2016·Ageing Research Reviews·A E MorganM T Mc Auley
Jan 24, 2017·Journal of the American Geriatrics Society·Mark A Supiano, Jeff D Williamson
Mar 28, 2017·European Journal of Heart Failure·Florian A SchmidFrank Enseleit
Jun 13, 2017·Heart Failure Clinics·Kumar Dharmarajan, Michael W Rich
Jul 1, 2017·F1000Research·Xian XiaJing-Dong Jackie Han
Oct 19, 2017·Age and Ageing·Gotaro KojimaKate Walters
Apr 8, 2018·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S Di MarcaL Malatino
Dec 19, 2018·Circulation. Heart Failure·Sandra L JacksonMatthew D Ritchey
Dec 21, 2018·The Journal of Nutrition, Health & Aging·S YaoX Wang
Jan 11, 2019·Journal of the American Geriatrics Society·Yue-Bin LvXiao-Ming Shi
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Sep 29, 2019·Aging Cell·Adiv A Johnson, Alexandra Stolzing
Jan 31, 2020·Irish Journal of Medical Science·Meltem KocaMustafa Cankurtaran