Cardiovascular Health in Young Adulthood and Association with Left Ventricular Structure and Function Later in Life: The Coronary Artery Risk Development in Young Adults Study

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Chintan S DesaiDonald M Lloyd-Jones

Abstract

The aim of this study was to determine the association between cardiovascular health (CVH) in young adulthood and left ventricular (LV) structure and function later in life. Participants from the Coronary Artery Risk Development in Young Adults study, which recruited black and white participants aged 18 to 30 years at baseline, were included; echocardiography was performed at year 25. CVH at year 0 was defined on the basis of blood pressure, total cholesterol, fasting glucose, body mass index, smoking status, diet, and physical activity. Two, 1, or 0 points were assigned to each component for ideal, intermediate, and poor levels of each component. Participants were stratified into CVH groups on the basis of point score: ≤ 8 (poor), 9 to 11 (intermediate), and 12 to 14 (ideal). The distribution of CVH at year 0 was as follows: poor, n = 264 (9%); intermediate, n = 1,315 (47%); and ideal, n = 1,224 (44%). Individuals with ideal and intermediate CVH at year 0 had significantly lower LV end-diastolic volume and lower LV mass index at year 25. In participants with ideal and intermediate CVH, the multivariate-adjusted odds ratios for diastolic dysfunction at year 25 was 0.52 (95% CI, 0.37-0.73) and 0.63 (95% CI, 0.46-0.83), respectiv...Continue Reading

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Citations

Jan 22, 2019·Journal of Strength and Conditioning Research·Antonio Garcia-HermosoRobinson Ramírez-Vélez
Jul 1, 2020·Circulation. Cardiovascular Quality and Outcomes·Joshua D BundyNorrina B Allen
Dec 26, 2018·Nutrients·Robinson Ramírez-VélezEmilio González-Jiménez
Nov 13, 2020·Journal of the American College of Cardiology·Amanda M PerakDonald M Lloyd-Jones
Nov 20, 2020·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Amanda M PerakDonald M Lloyd-Jones
Mar 20, 2019·Journal of Diabetes and Its Complications·Michael P BancksNorrina B Allen
Mar 26, 2021·Journal of the American Heart Association·Joshua D BundyNorrina B Allen
Jul 17, 2021·Journal of the American College of Cardiology·Donald M Lloyd-JonesJared P Reis
Aug 26, 2021·Circulation Research·Brian T JoyceDonald Lloyd-Jones

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