PMID: 8594317Jan 1, 1996Paper

Cardiovascular hypertrophy and increased vascular contractile responsiveness following repeated cocaine administration in rabbits

Life Sciences
R L SutliffM D Johnson

Abstract

The effects of repeated cocaine administration on contractile responses were studied in adult rabbits. Repeated cocaine exposure caused a significant increase in the maximal response of the aorta to the agonists norepinephrine and serotonin as well as the receptor- independent stimulus KCl when compared to the saline controls. Cocaine exposure caused a significant increase in the wet weights of both heart and aorta. When the contraction was normalized to the wet weight of the aorta there was no difference between rabbits administered cocaine and saline. Acute cocaine administration caused a time-dependent increase in immunoreactivity of the proto-oncogene c-Fos in the aorta. These results show that repeated cocaine administration leads to the development of cardiovascular hypertrophy.

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Citations

Feb 11, 2003·Pharmacology & Therapeutics·Mark M Knuepfer
Jun 21, 2005·Resuscitation·Manish M PatelMichael A Miller
Aug 18, 2004·Fundamental & Clinical Pharmacology·Fabienne MoritzChristian Thuillez
Aug 10, 1999·Toxicology and Applied Pharmacology·R L SutliffM D Johnson
Jan 11, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·R J HenningS Chiou
Jun 17, 2003·Journal of Cardiovascular Pharmacology and Therapeutics·Robert J Henning, Yongxiang Li
Aug 27, 2005·The Journal of Pharmacology and Experimental Therapeutics·Pratik ParikhRichard P Shannon

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