Cardiovascular Implications and Therapeutic Considerations in COVID-19 Infection

Cardiology and Therapy
Gregory L JudsonVaikom S Mahadevan

Abstract

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has profoundly impacted all fields of medicine. Infection with SARS-CoV-2 and the resulting coronavirus of 2019 (COVID-19) syndrome has multiorgan effects. The pandemic has united researchers from bench to bedside in attempts to understand the pathophysiology of the disease and define optimal treatment strategies. Cardiovascular disease is highly prevalent and a leading cause of death across gender, race, and ethnic groups. As the pandemic spreads, there is increasing concern about the cardiovascular effects of the viral infection and the interaction of infection with existing cardiovascular disease. Additionally, there are concerns about the cardiac effects of the numerous treatment agents under study. It will be essential for cardiologists to understand the interplay between underlying cardiac comorbidities, acute cardiovascular effects of COVID-19 disease, and adverse effects of new treatments. Here we describe emerging evidence of the epidemiology of SARS-CoV-2 infection and underlying cardiovascular disease, the evidence for direct myocardial injury in SARS-CoV-2 infection, the specific presentations of cardiovascular involvement by SARS-CoV-...Continue Reading

References

Jun 21, 2002·Nature·Michael A CrackowerJosef M Penninger
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Feb 8, 2006·Postgraduate Medical Journal·C-M YuJ J-Y Sung
May 21, 2009·European Journal of Clinical Investigation·G Y OuditJ Butany
Dec 18, 2010·American Journal of Public Health·Sandra Crouse QuinnKelley Kidwell
Oct 19, 2012·The New England Journal of Medicine·Ali M ZakiRon A M Fouchier
May 3, 2013·Immunopharmacology and Immunotoxicology·Ernst TönnesmannThorsten Lewalter
Feb 13, 2016·MMWR. Morbidity and Mortality Weekly Report·James L HadlerSandra S Chaves
Jul 13, 2016·Circulation·Robert L PageUNKNOWN American Heart Association Clinical Pharmacology and Heart Failure and Transplantation Committees of the Council on Clinical
May 12, 2017·Heart·Pietro Enea LazzeriniPier Leopoldo Capecchi
Jan 25, 2018·The New England Journal of Medicine·Jeffrey C KwongJonathan B Gubbay
Oct 28, 2019·Science·Ziad ObermeyerSendhil Mullainathan
Nov 28, 2019·The New England Journal of Medicine·Sabue MulanguUNKNOWN PALM Consortium Study Team
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 8, 2020·International Journal of Antimicrobial Agents·Philippe ColsonDidier Raoult
Mar 15, 2020·Progress in Cardiovascular Diseases·Giuseppe LippiFabian Sanchis-Gomar
Mar 15, 2020·The Lancet. Respiratory Medicine·Lei FangMichael Roth
Mar 18, 2020·Circulation. Cardiovascular Quality and Outcomes·Chor-Cheung Frankie TamChung-Wah Siu
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang
Mar 24, 2020·Journal of the American College of Cardiology·Elissa DrigginSahil A Parikh
Mar 29, 2020·JAMA Cardiology·Riccardo M InciardiMarco Metra
Mar 29, 2020·JAMA : the Journal of the American Medical Association·Chenguang ShenLei Liu
Apr 1, 2020·The New England Journal of Medicine·Pavan K BhatrajuCarmen Mikacenic
Apr 7, 2020·Circulation·Andrew R ChapmanNicholas L Mills
Apr 8, 2020·Circulation Research·Akbarshakh Akhmerov, Eduardo Marban

❮ Previous
Next ❯

Citations

Aug 5, 2020·Epilepsy & Behavior : E&B·Antonio-Carlos G de AlmeidaFulvio A Scorza

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT04342221
NCT04307693
NCT04315896
NCT04329923
NCT04345692
NCT04252885
NCT04255017
NCT04292899
NCT04292730
NCT04323761

Software Mentioned

NET

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved