Cardiovascular involvement in connective tissue disease: the role of interstitial lung disease

PloS One
XiaoBing WangLiangXing Wang

Abstract

The aim of this study was to assess cardiovascular involvement in patients with connective tissue disease (CTD), and determine whether interstitial lung disease (ILD) in these patients is associated with elevated cardiovascular risk. This study evaluated a retrospective cohort of 436 CTD patients admitted to a large teaching hospital in Zhejiang province, China, along with an additional 436 participants of an annual community health screening conducted in the physical examination center who served as age- and gender-matched controls. Demographic, clinical, serologic and imaging characteristics, as well as medications used by each participant were recorded. Cardiovascular involvement was defined by uniform criteria. Correlations between clinical/serologic factors and cardiovascular involvement were determined by univariate and multivariate analyses. CTD patients had a significantly higher cardiovascular involvement rate than controls (64.7% vs 23.4%), with higher rates of diabetes, hypertension, and hyperlipidemia, elevated systolic and diastolic pressures, C-reactive protein, total cholesterol, and low-density lipoprotein cholesterol, and lower albumin and high-density lipoprotein cholesterol (all p < 0.05). Furthermore, CTP pa...Continue Reading

References

May 1, 1997·American Journal of Respiratory and Critical Care Medicine·A U WellsR M du Bois
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·S E GayF J Martinez
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Jul 1, 1964·American Heart Journal·M R HEJTMANCIKF L JENNINGS
Mar 10, 2004·Archives of Internal Medicine·Jorge R KizerJohn Hansen-Flaschen
Feb 1, 2005·Journal of the American College of Cardiology·Frank HermannFrank Ruschitzka
Aug 27, 2005·Nature Clinical Practice. Cardiovascular Medicine·Sahena Haque, Ian N Bruce
Mar 30, 2006·Current Rheumatology Reports·Paul DeMarcoArthur Weinstein
Jun 15, 2007·Journal of Hypertension·Enrico ArosioAlessandro Lechi
Aug 28, 2007·Journal of the American College of Cardiology·Kaisa M Mäki-PetäjäIan B Wilkinson
Oct 31, 2007·Autoimmunity Reviews·Cristina C BeliznaYehuda Shoenfeld
Jan 30, 2008·Archives of Internal Medicine·Bernadette R GochuicoIvan O Rosas
May 21, 2008·International Journal of Chronic Obstructive Pulmonary Disease·Filippo Luca FimognariRaffaele Antonelli Incalzi
Sep 27, 2008·Autoimmunity Reviews·Simona SitiaMaurizio Turiel
Apr 2, 2009·The European Respiratory Journal·K M AntoniouN M Siafakas
Apr 28, 2009·Autoimmunity Reviews·Michael T Nurmohamed
Nov 17, 2009·Autoimmunity Reviews·Maurizio TurielPiercarlo Sarzi-Puttini
Jul 27, 2010·Current Opinion in Rheumatology·Adel BoueizPaul M Hassoun
Aug 10, 2010·Autoimmunity Reviews·Piercarlo Sarzi-PuttiniMaurizio Turiel
Mar 1, 2012·American Journal of Respiratory and Critical Care Medicine·Tracy J DoyleIvan O Rosas
Mar 20, 2012·Best Practice & Research. Clinical Rheumatology·Marta MoscaStefano Bombardieri

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