Cardiovascular magnetic resonance imaging in asymptomatic patients with connective tissue disease and recent onset left bundle branch block

International Journal of Cardiology
Sophie MavrogeniGeorge D Kitas

Abstract

Recent LBBB in connective tissue diseases (CTDs) is challenging, due to high incidence of underlying pathology that may remain undetected, due to limitations of imaging tests. We hypothesized that cardiovascular magnetic resonance (CMR) may be of diagnostic value in CTDs with recent LBBB and normal echocardiogram. 26 CTDs, aged 32 ± 7 yrs (19 F) and 26 controls without CTDs, aged 60 ± 4 yrs (10 F) with recent LBBB and normal echo were evaluated by CMR. The CTDs included 6 sarcoidosis (SRC), 4 systemic sclerosis (SSc), 6 systemic lupus erythematosus (SLE), 6 rheumatoid arthritis (RA) and 4 inflammatory myopathies (IM). CMR was performed by 1.5T. LVEF, T2 ratio (oedema imaging) and late gadolinium enhancement (LGE) (fibrosis imaging) were evaluated. Acute and chronic lesions were characterised by T2>2 and positive LGE and T2<2 and positive LGE, respectively. According to LGE, lesions were characterised as diffuse subendo-, subepicardial/intramural not following and subendocardial/transmural following the distribution of coronaries, indicative of vasculitis, myocarditis and myocardial infarction, respectively. CTDs were younger (p<0.001), with higher incidence of abnormal CMR (42.31 vs 30.77%, p=NS), including dilated cardiomyopat...Continue Reading

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Citations

Feb 16, 2016·Expert Review of Cardiovascular Therapy·Sophie I MavrogeniGeorge Theodorakis
Dec 1, 2015·Seminars in Arthritis and Rheumatism·Sophie I MavrogeniMaria G Tektonidou
Jan 13, 2018·Journal of Magnetic Resonance Imaging : JMRI·Liuyu YuYucheng Chen
Jul 12, 2018·Cardiology in Review·Zaneta SmolenskaZbigniew Zdrojewski
Mar 25, 2020·Current Opinion in Rheumatology·David Roofeh, Dinesh Khanna
Jul 19, 2017·BMC Cardiovascular Disorders·Sophie MavrogeniGenovefa Kolovou
Sep 18, 2020·International Journal of Cardiology·A BaritussioC Bucciarelli-Ducci
May 11, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Karen G OrdovasMonvadi B Srichai

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