Cardiovascular morbidity and mortality in peripheral arterial disease

Current Drug Targets. Cardiovascular & Haematological Disorders
Robert T Eberhardt, Jay D Coffman

Abstract

The term peripheral arterial disease (PAD) is often used to describe atherosclerosis involving the arteries supplying the lower extremities. Potentially modifiable factors that predispose to the development and progression of both symptomatic and asymptomatic PAD include smoking, diabetes mellitus, hyperlipidemia, and hypertension. Since the same risk factors for PAD predispose to the development of systemic atherosclerosis, identification of PAD increases the likelihood of coexistent coronary heart and cerebrovascular disease. Even after adjustment for risk factors, PAD appears to increase the risk for ischemic manifestations involving these other vascular territories with about a 2-fold increase in myocardial infarction and perhaps stroke. The most dramatic consequence of PAD is impaired survival with a 2- to 3-fold increased risk of 5- to 10-year mortality. While the adverse cardiovascular and cerebrovascular complications are highest for persons with more severe PAD, there is still a significant risk in persons with mild and even asymptomatic disease. The focus in the management of PAD should be on early diagnosis and efforts to reduce the risk of adverse events including risk factor modification and antiplatelet therapy.

Associated Clinical Trials

Citations

Nov 4, 2010·Cell Stress & Chaperones·Miklós KrepuskaGyörgy Acsády
May 10, 2007·Scandinavian Cardiovascular Journal : SCJ·Heikki PoussaMauri Lepäntalo
Jul 22, 2015·Cardiovascular Research·Gopi K KolluruChristopher G Kevil
Jun 16, 2010·Clinical Science·Matthijs S RuiterMaya S Huijberts
Jun 19, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·C A MeijerJ H N Lindeman
Nov 23, 2017·SAGE Open Medicine·Thomas MuellerBenjamin Dieplinger
Mar 13, 2008·Journal of Cardiovascular Medicine·Gregorio BrevettiMassimo Chiariello
Aug 26, 2010·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Phyllis A BonhamJacob Robison
May 4, 2006·Vascular Medicine·Gregorio BrevettiMassimo Chiariello
Jan 6, 2010·The Physician and Sportsmedicine·Keith Elizabeth PenaEli Carmeli
Jul 10, 2019·International Journal of Molecular Sciences·Senthilkumar ThulasingamElisabeth Deindl

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