Cardiovascular morbidity and mortality in community-dwelling elderly individuals with calcification of the fibrous skeleton of the base of the heart and aortosclerosis (The Cardiovascular Health Study)

The American Journal of Cardiology
Eddy BaraschAnne B Newman

Abstract

In the elderly, mitral annular calcification (MAC) and aortic valve sclerosis (AVS) are associated with increased cardiovascular morbidity and mortality. Aortic annular calcification (AAC) commonly occurs with MAC. However, the prognostic value of AAC, singly or in combination with MAC and AVS, for incident cardiovascular disease and mortality is unknown. From the Cardiovascular Health Study, we analyzed 3,782 participants (76 +/- 5 years of age, 60% women) who had an echocardiogram at the 1994 to 1995 examination and who were prospectively followed for an average of 6.6 years (range 0.01 to 8.5). All 3 calcification categories were associated with incident congestive heart failure (MAC: hazard ratio [HR] 1.71, 95% confidence interval [CI] 1.35 to 2.18, AAC: HR 1.62, 95% CI 1.28 to 2.06, and AVS: HR 1.50, 95% CI 1.19 to 1.89) and death. A stronger association with incident cardiovascular disease and mortality was observed with a larger number of calcification categories and with increased MAC severity. Moreover, in the participants with prevalent cardiovascular disease at echocardiographic examination (n = 1,054), MAC and AAC were still associated with cardiovascular mortality (MAC: HR 1.91, 95% CI 1.04 to 3.50; AAC: HR 2.11, 9...Continue Reading

References

Aug 6, 1992·The New England Journal of Medicine·E J BenjaminD Levy
Feb 1, 1991·Annals of Epidemiology·L P FriedA Newman
Jan 1, 1992·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·J M GardinT A Manolio
Sep 1, 1986·The American Journal of Cardiology·W C Roberts
Sep 1, 1996·Stroke; a Journal of Cerebral Circulation·T A ManolioT R Price
Jul 15, 1999·The New England Journal of Medicine·C M OttoD S Siscovick
May 12, 2000·Journal of the American College of Cardiology·J S GottdienerR C Boineau

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Citations

Feb 14, 2013·General Thoracic and Cardiovascular Surgery·Yukikatsu Okada
Mar 16, 2007·Cardiovascular Ultrasound·Mohammad-Reza MovahedRamin Ebrahimi
Jun 28, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Paolo RaggiPaul Muntner
Nov 16, 2013·International Journal of Cardiology·Danitza PradelliPompilio Faggiano
Mar 15, 2011·International Journal of Cardiology·Fadi G HageNavin C Nanda
Nov 20, 2009·Atherosclerosis·Henry VölzkeMarcus Dörr
Oct 15, 2009·Anesthesiology Clinics·Charles Z Zigelman, Patti M Edelstein
Aug 28, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joachim H IxKevin D O'Brien
Jan 5, 2011·Echocardiography·Ayodeji AdegunsoyeFadi G Hage
Feb 8, 2011·The American Journal of Medicine·S Michael GharacholouPatricia A Pellikka
Oct 10, 2013·BioMed Research International·Gregg S PressmanVincent M Figueredo
May 11, 2015·Metabolism: Clinical and Experimental·Alessandro MantovaniGiovanni Targher
Apr 18, 2015·JACC. Cardiovascular Imaging·Julius M Gardin
Apr 29, 2014·International Journal of Cardiology·Nicola GaibazziPompilio Faggiano
Jan 1, 2013·Atherosclerosis·Atif N QasimMuredach P Reilly
Oct 16, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marvin Louis Roy LuGregg S Pressman
Oct 26, 2016·Stroke; a Journal of Cerebral Circulation·Daniel BosAad van der Lugt
Jul 31, 2013·Expert Review of Cardiovascular Therapy·George LazarosNalini Rajamannan
Dec 29, 2007·Journal of Cardiovascular Medicine·Annamaria MazzoneSergio Berti
Sep 20, 2020·Echocardiography·Tom Kai Ming WangMilind Y Desai
Nov 20, 2019·European Heart Journal Cardiovascular Imaging·Parveen K GargMatthew Allison
Aug 9, 2020·Clinical Interventions in Aging·Paolo CarraiCarla Caffarelli

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