Cardiovascular outcomes associated with concomitant use of clopidogrel and proton pump inhibitors in patients with acute coronary syndrome in Taiwan.

British Journal of Clinical Pharmacology
Chen-Fang LinChurn-Shiouh Gau

Abstract

Conflicting results have been reported regarding the increased risk of adverse outcomes in the concomitant use of clopidogrel and proton pump inhibitors (PPIs) compared with the use of clopidogrel alone. Our study indicated no statistically significant increase in the risk of rehospitalization for acute coronary syndrome due to concurrent use of clopidogrel and PPIs in an Asian population with higher prevalence of CYP2C19 intermediate and poor metabolizers. Among all PPIs, only omeprazole was found to be statistically significantly associated with an increased risk of rehospitalization for acute coronary syndrome. AIMS Our study aimed to examine the impact of concomitant use of proton pump inhibitors (PPIs) with clopidogrel on the cardiovascular outcomes of patients with acute coronary syndrome (ACS). Furthermore, we sought to quantify the effects of five individual PPIs when used concomitantly with clopidogrel. We conducted a retrospective cohort study of patients who were newly hospitalized for ACS between 1 January 2006 and 31 December 2007 retrieved from the Taiwan National Health Insurance Research Database (NHIRD) and who were prescribed clopidogrel (n= 37 099) during the follow-up period. A propensity score technique was...Continue Reading

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Citations

Jun 19, 2012·European Journal of Clinical Pharmacology·Jia WuJian-Ting Cai
Mar 29, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Tommy AnderssonLars Wallentin
Jul 22, 2018·European Journal of Gastroenterology & Hepatology·Md Mohaimenul IslamYu-Chuan Jack Li
Mar 21, 2019·São Paulo Medical Journal = Revista Paulista De Medicina·Marcela ForgeriniPatrícia de Carvalho Mastroianni
Jul 2, 2020·International Journal of Clinical Pharmacy·Qingqing ChenYun Liao
Dec 27, 2016·Journal of Gastroenterology and Hepatology·Duowu Zou, Khean-Lee Goh

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