Cardiovascular Outcomes of Cholinesterase Inhibitors in Individuals with Dementia: A Meta-Analysis and Systematic Review

Journal of the American Geriatrics Society
Ahmet Turan IsikChristoph Mueller

Abstract

To evaluate the cardiovascular (CV) effects of acetylcholinesterase inhibitors (AChEIs) in individuals with dementia DESIGN: Systematic review and meta-analysis. Two authors independently searched major electronic databases from inception until June 17, 2017, for longitudinal (without a control group) and cohort (with a control group) studies reporting CV outcomes in relation to AChEIs. Randomized controlled trials were excluded because they included relatively healthy subjects. Individuals with dementia and controls. Changes in CV parameters were summarized using standardized mean differences (SMDs) with 95% confidence intervals (CIs). Event rates were used to assess incidence of hypertension and bradycardia. Incidence of CV events in demented patients versus in healthy controls were compared using hazard ratios (HRs). Of 4,588 initial hits, 31 studies including 258,540 individuals with dementia and 2,246,592 controls were analyzed. In longitudinal and open-label studies, AChEIs were associated with a significantly greater incidence of hypertension (n=1,573, 4%, 95% CI=2-8%, I2 =47%) and bradycardia (n=13,703, 2%, 95% CI=1-6%, I2 =98%). AChEIs were associated with a decrease in heart rate (SMD=-1.77, 95% CI=-3.58-0.03, I2 =78%...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Mar 11, 2003·Dementia and Geriatric Cognitive Disorders·A T McLarenR A Kenny
Mar 12, 2005·Journal of the Neurological Sciences·Barbara BorroniAlessandro Padovani
Oct 27, 2007·Stroke; a Journal of Cerebral Circulation·Karl-Jürgen BärHeinrich Sauer
Sep 13, 2008·Primary Care Companion to the Journal of Clinical Psychiatry·Gary S FigielIbrahim Gunay
Jan 23, 2009·Primary Care Companion to the Journal of Clinical Psychiatry·Gary S FigielIbrahim Gunay
Mar 19, 2009·American Journal of Alzheimer's Disease and Other Dementias·Carl H SadowskyUNKNOWN US38 study group
Sep 30, 2009·PLoS Medicine·Laura Y Park-WyllieDavid N Juurlink
Oct 2, 2009·Journal of the American Geriatrics Society·Rohini K HernandezElizabeth V Lawler
Apr 8, 2010·Journal of the American Geriatrics Society·Arenda H E A van BeekJurgen A H R Claassen
Jul 29, 2010·Clinical Pharmacology and Therapeutics·K SatoA Diedrich
Nov 26, 2010·Clinical Interventions in Aging·Ahmet Turan Isik
Jan 5, 2011·Geriatrics & Gerontology International·Katrien Van PuyveldeUNKNOWN RODOS Study Group
Feb 22, 2011·The American Journal of Geriatric Pharmacotherapy·Ahmet Turan IsikSelim Kilic
Mar 28, 2012·Internal Medicine·Ahmet Turan IsikEmine Aydemir
May 11, 2012·American Journal of Alzheimer's Disease and Other Dementias·Ahmet Turan IsikUmit Ateskan
Dec 12, 2012·The American Journal of Geriatric Pharmacotherapy·Edeltraut KrögerToine Egberts
Jul 10, 2013·Current Medicinal Chemistry·D TsvetkovaL Saso
May 29, 2014·American Journal of Alzheimer's Disease and Other Dementias·Ahmet Turan IsikAdnan Yay
Dec 23, 2015·Journal of the American Geriatrics Society·Pinar Soysal, Ahmet Turan Isik
Jun 5, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Pinar SoysalNicola Veronese

❮ Previous
Next ❯

Citations

Sep 17, 2020·Future Cardiology·Mark DayerStuart D Rosen
Nov 15, 2019·Epidemiology and Psychiatric Sciences·T MöllersH Brenner
Sep 17, 2019·Journal of Alzheimer's Disease : JAD·Miika LinnaTero Ylisaukko-Oja
Oct 5, 2018·Journal of Alzheimer's Disease : JAD·Pierre Krolak-SalmonArmand Perret-Liaudet
Aug 12, 2018·Journal of the American Geriatrics Society·Holly M Holmes, Rajender R Aparasu
Oct 6, 2020·Annals of Neurology·Alberto J EspayBaltazar Gomez-Mancilla
Aug 19, 2020·Alzheimer Disease and Associated Disorders·Ahmet T IsikMehmet S Ontan
Feb 5, 2021·Mechanisms of Ageing and Development·Jacopo SabbatinelliFabiola Olivieri
Jan 19, 2021·Journal of the American Geriatrics Society·Jennifer A WattSusan E Bronskill
Sep 3, 2021·Journal of the American Medical Directors Association·Delia BisharaChristoph Mueller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Related Papers

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Kun ChuWen Li
Journal of Cardiovascular Pharmacology
Daniel CaldeiraJoaquim J Ferreira
© 2022 Meta ULC. All rights reserved