Cardiovascular outcomes of pregnancy in Turner syndrome.

Heart
Jasmine GrewalAARCC Investigators

Abstract

Women with Turner syndrome (TS) are frequently counselled against pregnancy due to lack of data and unclear aortic dissection risk. However, with advances in fertility therapy, more women with TS are contemplating pregnancy. This study compared rates of adverse cardiovascular (CV) outcomes among: (1) pregnant and non-pregnant women with TS and (2) pregnant women with TS with/without structural heart disease. Retrospective analysis of pregnant and age-matched non-pregnant controls with TS (2005-2017) across 10 CV centres was done. Data were collected at initial evaluation in pregnancy and outcomes were assessed to 6 months postpartum. Adverse CV events were defined as CV death, aortic dissection/rupture and/or aortic intervention. Non-pregnant age-matched controls were followed over the same time period. Sixty-eight pregnancies were included (60 women, mean age 33 years, 48% primigravid, 49% fertility therapy, 80% structurally normal heart, 25% XO karyotype). Based on American Society of Reproductive Medicine criteria, 10 pregnancies occurred in women stratified to high-risk category. There were no CV events in the pregnant women or in the non-pregnant women with TS. Obstetric events complicated 12 (18%) pregnancies with 9 (13%)...Continue Reading

References

Mar 19, 2002·Journal of Medical Genetics·V P Sybert
Mar 21, 2002·Clinical Genetics·N H BirkebaekG Bruun-Petersen
Sep 13, 2003·Fertility and Sterility·Megan Freebury KarnisRichard Henry Reindollar
Sep 21, 2006·Cardiology in the Young·Claus Højbjerg GravholtJens Sandahl Christiansen
Jul 3, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Laure CabanesDelphine Zénaty
Dec 15, 2010·The Journal of Clinical Endocrinology and Metabolism·Nicolas ChevalierUNKNOWN French Study Group for Oocyte Donation
Sep 25, 2012·International Journal of Cardiology·Liat S GutinCarolyn A Bondy
Oct 12, 2015·La Presse médicale·Capucine Coulon
Feb 14, 2016·Human Reproduction·Valérie BernardUNKNOWN for CMERC Center for Rare Disease
Jul 15, 2017·European Journal of Endocrinology·Claus H GravholtUNKNOWN International Turner Syndrome Consensus Group
Aug 11, 2018·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Florence CadoretOlivier Parant
Oct 26, 2018·Circulation. Genomic and Precision Medicine·Michael SilberbachUNKNOWN American Heart Association Council on Cardiovascular Disease in the Young; Council on Genomic and Precision Medicine; and Co

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Citations

Sep 18, 2021·The Canadian Journal of Cardiology·Julia SmithNatalie Dayan

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