Cardiovascular pathobiology of inflammasomes: inflammatory machinery and beyond

Antioxidants & Redox Signaling
Pin-Lan Li

Abstract

In response to infection or cellular stress, inflammasomes are assembled and activated to mediate host defense and to initiate or promote the development of different diseases, in particular, autoinflammatory diseases and chronic degenerative diseases. Understanding of inflammasomes and related physiological and pathological relevance to the cardiovascular system will open a new chapter on the pathogenesis of inflammation and related diseases and will help develop novel therapeutic strategies for prevention or treatment of cardiovascular diseases. The inflammasome, in particular the nucleotide oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome, has been recently recognized as a fundamental mechanism to mediate or promote the pathogenesis of degenerative diseases. Some important mechanisms responsible for NLRP3 inflammasome activation have been proposed and many molecular targets associated with this inflammasome activation are shown to be the possible candidates of therapeutic targets for treatment of cardiovascular diseases. The concepts that NLRP3 inflammasome activation occurs just in immune cells or phagocytes and that its role is only for the inflammatory progression of cardiovascular disea...Continue Reading

References

Jul 2, 2014·Nature Reviews. Drug Discovery·Asher Mullard
Oct 3, 2014·Antioxidants & Redox Signaling·Nathan A BraceyDaniel A Muruve
Oct 3, 2014·Antioxidants & Redox Signaling·Islam N MohamedAzza B El-Remessy
Oct 21, 2014·Antioxidants & Redox Signaling·Carol M Artlett, James D Thacker
Oct 21, 2014·Antioxidants & Redox Signaling·Stefano ToldoAntonio Abbate
Oct 21, 2014·Antioxidants & Redox Signaling·Justine M AbaisPin-Lan Li
Nov 12, 2014·Antioxidants & Redox Signaling·Xiaojie Wang, Fan Yi

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Citations

Jan 6, 2017·Nature Reviews. Cardiology·Elísabet Alcocer-Gómez, Mario D Cordero
Dec 15, 2016·Antioxidants & Redox Signaling·Pedro BullónMario D Cordero
Nov 23, 2017·European Journal of Preventive Cardiology·Juan C Garcia-RubiraPedro Bullon
Jun 20, 2020·Medicine and Science in Sports and Exercise·Jonghae LeeYoonjung Park

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